Data Supplement
Files in this Data Supplement:
- Supplemental Data -
Supplemental Figure 1 - Surface rendering of the putative anesthetic binding site in the TASK-3 homology model
Supplemental Figure 2 - LyTASK and TASK-1 channel function is activated by halogenated ethanols
Supplemental Figure 3 - Comparison of 10 mM 2,2,2-trichloroethanol activation of TASK-3 at residues- 132 to -140
Supplemental Figure 4- 2,2,2-tribromoethanol (TBE) activates "yeast optimized" wild-type TASK-3, but not "yeast optimized" V136E rTASK-3
Supplemental Figure 5 -Trk1p and "yeast optimized" TASK-3 promote trk1-Delta-trk2-Delta Saccharomyces cerevisiae growth in low potassium media
Supplemental Figure 6 - Rate of yeast growth in the presence of 2,2,2-tribromoethanol (TBE)
Supplemental Table 1 - Anesthetic concentration (in mM) required for loss of righting reflex in Xenopus laevis tadpoles