2 July 2009

Joo-Yun Byun, Min-Jung Kim, Da-Young Eum, Chang-Hwan Yoon, Woo-Duck Seo, Ki Hun Park, Jin-Won Hyun, Yun-Sil Lee, Jae-Sung Lee, Moon-Young Yoon, and Su-Jae Lee

Reactive oxygen species-dependent activation of Bax and PARP-1 is required for mitochondrial cell death induced by triterpenoid pristimerin in human cervical cancer cells
Published July 2, 2009; doi: 10.1124/mol.109.056259 [Abstract] [PDF] [Data Supplement]  

1 July 2009

Yi-Ching Hsieh, Nancy E Skacel, Nitu Bansal, Kathleen W Scotto, Debabrata Banerjee, Joseph R Bertino, and Emine Ercikan Abali

Species Specific Differences in Translational Regulation of Dihydrofolate Reductase
Published July 1, 2009; doi: 10.1124/mol.109.055772 [Abstract] [PDF]  

Xi-Ping Huang, Vincent Setola, Prem N Yadav, John A Allen, Sarah C Rogan, Bonnie J Hanson, Chetana Revankar, Matt Robers, Chris Doucette, and Bryan L Roth

Parallel functional activity profiling reveals valvulopathogens are potent 5-HT_2B receptor agonists: implications for drug safety assessment
Published July 1, 2009; doi: 10.1124/mol.109.058057 [Abstract] [PDF] [Data Supplement]  

David Maussang, Henry F Vischer, Rob Leurs, and Martine J Smit

Herpesvirus-encoded G protein-coupled receptors as modulators of cellular function
Published July 1, 2009; doi: 10.1124/mol.109.057091 [Abstract] [PDF]  

Sayaka Komagata, Miki Nakajima, Shingo Takagi, Takuya Mohri, Takao Taniya, and Tsuyoshi Yokoi

Human CYP24 catalyzing the inactivation of calcitriol is post-transcriptionally regulated by miR-125b
Published July 1, 2009; doi: 10.1124/mol.109.056986 [Abstract] [PDF]  

Zheng D. Liang, David Stockton, Niramol savaraj, and Macus T. Kuo

Mechanistic Comparison of Human Copper Transporter hCtr1-Mediated Transports between Copper Ion and Cisplatin
Published July 1, 2009; doi: 10.1124/mol.109.056416 [Abstract] [PDF]  

Francis Edwin, Kimberly Anderson, Chunyi Ying, and Tarun B Patel

Intermolecular interactions of Sprouty Proteins and their implications in development and disease
Published July 1, 2009; doi: 10.1124/mol.109.055848 [Abstract] [PDF]  

26 June 2009

David Hermanson, Sadiya N Addo, Anna A Bajer, Jonathan S Marchant, Sonia G Das, Balasubramanian Srinivasan, Fawaz Al-Mousa, Francesco Michelangeli, David D Thomas, Tucker W LeBien, and Chengguo Xing

Dual Mechanisms of sHA 14-1 in Inducing Cell Death through Endoplasmic Reticulum and Mitochondria
Published June 26, 2009; doi: 10.1124/mol.109.055830 [Abstract] [PDF]  

Naushaba Nayeem, Yihong Zhang, Devin K Schweppe, Dean R Madden, and Tim Green

A non-desensitizing kainate receptor point mutant
Published June 26, 2009; doi: 10.1124/mol.109.056598 [Abstract] [PDF]  

25 June 2009

Gretchen Y Lopez-Hernandez, Jeffrey S Thinschmidt, Guangrong Zheng, Zhenfa Zhang, Peter A Crooks, Linda P. Dwoskin, and Roger L Papke

Selective inhibition of acetylcholine-evoked responses of 7 neuronal nicotinic acetylcholine receptors by novel tris- and tetrakis-azaaromatic quaternary ammonium antagonists
Published June 25, 2009; doi: 10.1124/mol.109.056176 [Abstract] [PDF]  

24 June 2009

Sean M O'Shea, Carrie A Williams, and Andrew Jenkins

Inverse Effects on Gating and Modulation Caused by a Mutation in the M2-3 Linker of the GABA_A Receptor Gamma Subunit
Published June 24, 2009; doi: 10.1124/mol.109.055111 [Abstract] [PDF] [Data Supplement]  

23 June 2009

Peidong Fan, Zhan Jiang, Ivan Diamond, and Lina Yao

Up-regulation of AGS3 during morphine withdrawal promotes cAMP superactivation via adenylyl cyclase 5 and 7 in rat nucleus accumbens/striatal neurons
Published June 23, 2009; doi: 10.1124/mol.109.057802 [Abstract] [PDF]  

Travis W. Day, Ching-Huang Wu, and Ahmad R. Safa

Etoposide Induces Protein Kinase C - and Caspase-3-dependent Apoptosis in Neuroblastoma Cancer Cells
Published June 23, 2009; doi: 10.1124/mol.109.054999 [Abstract] [PDF]  

19 June 2009

Pari Malherbe, Edilio Borroni, Emmanuel Pinard, Joseph G. Wettstein, and Frederic Knoflach

Biochemical and electrophysiological characterization of almorexant, a dual OX₁/OX₂ antagonist: comparison with selective OX₁ and OX₂ antagonists
Published June 19, 2009; doi: 10.1124/mol.109.055152 [Abstract] [PDF]  

Nageswararao Chilukuri, Ellen G Duysen, Kalpana Parikh, Robert diTargiani, Bhupendra P Doctor, Oksana Lockridge, and Ashima Saxena

Adenovirus transduced human butyrylcholinesterase in mouse blood functions as a bioscavenger of chemical warfare nerve agents
Published June 19, 2009; doi: 10.1124/mol.109.055665 [Abstract] [PDF]  

Ming-Jie Liu, Yuki Takahashi, Taira Wada, Jinhan He, Jie Gao, Yana Tian, Song Li, and Wen Xie

The aldo-keto reductase Akr1b7 gene is a common transcriptional target of xenobiotic receptors PXR and CAR
Published June 19, 2009; doi: 10.1124/mol.109.057455 [Abstract] [PDF]  

18 June 2009

Lijun Zhou, Jingjing Zhang, Qichen Fang, Meilian Liu, Xiangling Liu, Weiping Jia, Lily Q Dong, and Feng Liu

Autophagy-mediated Insulin Receptor Down-regulation Contributes to ER Stress-induced Insulin Resistance
Published June 18, 2009; doi: 10.1124/mol.109.057067 [Abstract] [PDF]  

17 June 2009

Cong Wei, Peijuan Zhu, Sumit J. Shah, and Ian Alexander Blair

15-Oxo-Eicosatetraenoic Acid, a Metabolite of Macrophage 15-Hydroxyprostaglandin Dehydrogenase that Inhibits Endothelial Cell Proliferation
Published June 17, 2009; doi: 10.1124/mol.109.057489 [Abstract] [PDF]  

15 June 2009

Erin R Tuller, Charles T Beavers, Jessica R Lou, Doris M Benbrook, Michael A Ihnat, and Wei-Qun Ding

Docosahexaenoic acid inhibits superoxide dismutase 1 gene transcription in human cancer cells: the involvement of PPAR and HIF-2 signaling
Published June 15, 2009; doi: 10.1124/mol.109.057430 [Abstract] [PDF]  

12 June 2009

Hongfei Zhou, Jadwiga K Kepa, David Siegel, Shigenori Miura, Yuji Hiraki, and David Ross

BENZENE METABOLITE HYDROQUINONE UP-REGULATES CHONDROMODULIN-I AND INHIBITS TUBE FORMATION IN HUMAN BONE MARROW ENDOTHELIAL CELLS
Published June 12, 2009; doi: 10.1124/mol.109.057323 [Abstract] [PDF]  

11 June 2009

Poulomi Acharya, Juan C. Engel, and Maria Almira Correia

Hepatic CYP3A suppression by high concentrations of proteasomal inhibitors: A consequence of endoplasmic reticulum (ER)-stress induction, activation of PERK and GCN2 eIF2 kinases and global translational shut-off
Published June 11, 2009; doi: 10.1124/mol.109.056002 [Abstract] [PDF] [Data Supplement]  

10 June 2009

Charlotte Hougaard, Marianne L. Jensen, Tim J. Dale, David D. Miller, David J. Davies, Birgitte L. Eriksen, Dorte Strobaek, Derek J. Trezise, and Palle Christophersen

Selective Activation of the SK1 Subtype of Human Small Conductance Ca²⁺-Activated K⁺ Channels by GW542573X is Dependent on Serine 293 in the S5 Segment
Published June 10, 2009; doi: 10.1124/mol.109.056663 [Abstract] [PDF]  

Sun-Young Ahn and Sanjay K. Nigam

Toward a Systems Level Understanding of Organic Anion and Other Multispecific Drug Transporters: A Remote Sensing and Signaling Hypothesis
Published June 10, 2009; doi: 10.1124/mol.109.056564 [Abstract] [PDF]  

9 June 2009

Genaro Barrientos, Diptiman D. Bose, Wei Feng, Isela Padilla, and Isaac N. Pessah

The Na⁺/Ca²⁺ exchange inhibitor KB-R7943 also blocks ryanodine receptors type 1 (RyR1) and type 2 (RyR2) channels
Published June 9, 2009; doi: 10.1124/mol.109.057265 [Abstract] [PDF]  

Nicole Toohey, Michael T. Klein, Jessica Knight, Carol Smith, and Milt Teitler

Human 5-HT₇ receptor-induced inactivation of forskolin-stimulated adenylate cyclase by risperidone, 9-OH-risperidone and other "inactivating antagonists"
Published June 9, 2009; doi: 10.1124/mol.109.056283 [Abstract] [PDF]  

4 June 2009

Hao Jiang, Kristen E. Bower, Albert E. Beuscher, Bin Zhou, Andrey A. Bobkov, Arthur J. Olson, and Peter K. Vogt

Stabilizers of the Max Homodimer Identified in Virtual Ligand Screening Inhibit Myc Function
Published June 4, 2009; doi: 10.1124/mol.109.054858 [Abstract] [PDF] [Data Supplement]  

David A Sykes, Mark R Dowling, and Steven J Charlton

Exploring the mechanism of agonist efficacy: A relationship between efficacy and agonist dissociation rate at the muscarinic M₃ receptor
Published June 4, 2009; doi: 10.1124/mol.108.054452 [Abstract] [PDF]  

2 June 2009

Gerald W Dorn and Stephen B. Liggett

Mechanisms of Pharmacogenomic Effects of Genetic Variation of the Cardiac Adrenergic Network in Heart Failure
Published June 2, 2009; doi: 10.1124/mol.109.056572 [Abstract] [PDF]  

1 June 2009

Manveen K Gupta, Robert S Papay, Chris WD Jurgens, Robert J Gaivin, Ting Shi, Van A Doze, and Dianne M. Perez

₁-Adrenergic Receptors Regulate Neurogenesis and Gliogenesis
Published June 1, 2009; doi: 10.1124/mol.109.057307 [Abstract] [PDF]  

Lifen Zhang, William M Doyon, Jeremy J Clark, Paul E.M. Phillips, and John A Dani

Controls of Tonic and Phasic Dopamine Transmission in the Dorsal and Ventral Striatum
Published June 1, 2009; doi: 10.1124/mol.109.056317 [Abstract] [PDF] [Data Supplement]  

Dong Gui Hu and Peter Ian MacKenzie

Estrogen Receptor , Fos-Related Antigen-2 and c-Jun co-ordinately regulate human UDP glucuronosyltransferase 2B15 and 2B17 expression in response to 17-estradiol in MCF-7 cells
Published June 1, 2009; doi: 10.1124/mol.109.057380 [Abstract] [PDF]  

Petrine Wellendorph, Lars D. Johansen, and Hans Brauner-Osborne

Molecular pharmacology of promiscuous 7TM receptors sensing organic nutrients
Published June 1, 2009; doi: 10.1124/mol.109.055244 [Abstract] [PDF]  

29 May 2009

Michael Holinstat, Anita M Preininger, Stephen B Milne, Willie James Hudson, H Alex Brown, and Heidi E Hamm

Irreversible platelet activation requires PAR1-mediated signaling to phosphatidylinositol phosphates
Published May 29, 2009; doi: 10.1124/mol.109.056622 [Abstract] [PDF]  

David J. Waxman and Minita G Holloway

Centennial Perspective: Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes
Published May 29, 2009; doi: 10.1124/mol.109.056705 [Abstract] [PDF]  

Teneille Walker, Clint Mitchell, Margaret A Park, Adly Yacoub, Martin Graf, Mohamed Rahmani, Peter J Houghton, Christina Voelkel-Johnson, Steven Grant, and Paul Dent

Sorafenib and Vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms
Published May 29, 2009; doi: 10.1124/mol.109.056523 [Abstract] [PDF]  

Aditi Pandya Martin, Margaret A Park, Clint Mitchell, Teneille Walker, Mohamed Rahmani, Andrew Thorburn, Dieter Haussinger, Roland Reinehr, Steven Grant, and Paul Dent

BCL-2 family inhibitors enhance HDACI+sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing
Published May 29, 2009; doi: 10.1124/mol.109.056309 [Abstract] [PDF] [Data Supplement]  

Stepan Aleshin, Sevil Grabeklis, Theodor Hanck, Marina Sergeeva, and Georg Reiser

PPARpositively and PPAR negatively control COX-2 expression in rat brain astrocytes through a convergence on PPAR/ via mutual control of PPAR expression levels
Published May 29, 2009; doi: 10.1124/mol.109.056010 [Abstract] [PDF]  

Timothy J. Davis, Deborah D. Soto-Ortega, Joseph A. Kotarek, Francisco J. Gonzalez-Velasquez, Krishnamoothy Sivakumar, Laying Wu, Qian Wang, and Melissa A. Moss

Comparative study of inhibition at multiple stages of amyloid- self assembly provides mechanistic insight
Published May 29, 2009; doi: 10.1124/mol.109.055301 [Abstract] [PDF]  

Dmytro Berezhnoy, Terrell T. Gibbs, and David H. Farb

Docking of 1,4-benzodiazepines in the ₁/₂ GABA_AR modulator site
Published May 29, 2009; doi: 10.1124/mol.109.054650 [Abstract] [PDF] [Data Supplement]  

20 May 2009

Nadia Lampiasi, Antonina Azzolina, Natale D'Alessandro, Kazuo Umezawa, James A McCubrey, Giuseppe Montalto, and Melchiorre Cervello

Antitumor effects of DHMEQ, a novel NF-B inhibitor, in human liver cancer cells is mediated through a reactive oxygen species-dependent mechanism
Published May 20, 2009; doi: 10.1124/mol.109.055418 [Abstract] [PDF]  

15 May 2009

Stephen B Shears

Diphosphoinositol Polyphosphates: Metabolic Messengers?
Published May 15, 2009; doi: 10.1124/mol.109.055897 [Abstract] [PDF]  

13 May 2009

Deanne J Mitchell and Rodney F Minchin

Cytosolic Aryl Sulfotransferase 4A1 Interacts with the Peptidyl Prolyl Cis-Trans Isomerase Pin1
Published May 13, 2009; doi: 10.1124/mol.109.055442 [Abstract] [PDF]  

Gemma Molinaro, Anna Traficante, Barbara Riozzi, Luisa Di Menna, Martina Curto, Simone Pallottino, Ferdinando Nicoletti, Valeria Bruno, and Giuseppe Battaglia

ACTIVATION OF mGlu2/3 METABOTROPIC GLUTAMATE RECEPTORS NEGATIVELY REGULATES THE STIMULATION OF INOSITOL PHOSPHOLIPID HYDROLYSIS MEDIATED BY 5-HT_2A SEROTONIN RECEPTORS IN THE FRONTAL CORTEX OF LIVING MICE
Published May 13, 2009; doi: 10.1124/mol.109.056580 [Abstract] [PDF]  

12 May 2009

Christopher Volk, Valentin Gorboulev, Alexander Kotzsch, Thomas D. Mueller, and Hermann Koepsell

Five Amino Acids in the Innermost Cavity of the Substrate Binding Cleft of Organic Cation Transporter 1 Interact with Extracellular and Intracellular Corticosterone
Published May 12, 2009; doi: 10.1124/mol.109.054783 [Abstract] [PDF]  

8 May 2009

Fan Gao, Kaleeckal G. Harikumar, Maoqing Dong, Polo C.-H. Lam, Patrick M. Sexton, Arthur Christopoulos, Andrew Bordner, Ruben Abagyan, and Laurence J. Miller

Functional importance of a structurally-distinct homo-dimeric complex of the Family B G protein-coupled secretin receptor
Published May 8, 2009; doi: 10.1124/mol.109.055756 [Abstract] [PDF]  

1 May 2009

Sean C. Barron, James T. McLaughlin, Jennifer A. See, Vanessa L Richards, and Robert L Rosenberg

The allosteric modulator of 7 nicotinic receptors, PNU-120596, causes conformational changes in the extracellular ligand binding domain similar to acetylcholine
Published May 1, 2009; doi: 10.1124/mol.109.056226 [Abstract] [PDF] [Data Supplement]  

Sheng-Chun Mao, Hui-Ching Lin, and Po-Wu Gean

Augmentation of fear extinction by infusion of glycine transporter blockers into the amygdala
Published May 1, 2009; doi: 10.1124/mol.108.053728 [Abstract] [PDF] [Data Supplement]  

30 April 2009

Douglas J. Sheffler, Richard Williams, Thomas M. Bridges, Zixiu Xiang, Alexander S. Kane, Nellie E. Byun, Satyawan Jadhav, Mathew M. Mock, Fang Zheng, L. Michelle Lewis, Carrie K. Jones, Colleen M. Niswender, Charles D. Weaver, Craig W. Lindsley, and P. Jeffrey Conn

A Novel Selective Muscarinic Acetylcholine Receptor Subtype 1 (M₁ mAChR) Antagonist Reduces Seizures Without Impairing Hippocampal-Dependent Learning
Published April 30, 2009; doi: 10.1124/mol.109.056531 [Abstract] [PDF] [Data Supplement]  

23 April 2009

Tatyana D Sotnikova, Marc G Caron, and Raul R Gainetdinov

Trace amine associated receptors (TAARs) as emerging therapeutic targets
Published April 23, 2009; doi: 10.1124/mol.109.055970 [Abstract] [PDF]  

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