Most-Cited Articles as of October 1, 2009 -- updated monthly.

Rankings based on citations to online articles from HighWire-hosted articles.

    • J Garthwaite,
    • E Southam,
    • C L Boulton,
    • E B Nielsen,
    • K Schmidt,
    • and B Mayer
    Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one. Mol Pharmacol August 1995 48:184-188
    • S Grissmer,
    • A N Nguyen,
    • J Aiyar,
    • D C Hanson,
    • R J Mather,
    • G A Gutman,
    • M J Karmilowicz,
    • D D Auperin,
    • and K G Chandy
    Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. Mol Pharmacol June 1994 45:1227-1234
  3. Article:
    • Toshimasa Ishizaki,
    • Masayoshi Uehata,
    • Ichiro Tamechika,
    • Jeongsin Keel,
    • Kimiko Nonomura,
    • Midori Maekawa,
    • and Shuh Narumiya
    Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases Mol Pharmacol May 1, 2000 57:976-983
    • K Williams
    Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors. Mol Pharmacol October 1993 44:851-859
    • C M Flores,
    • S W Rogers,
    • L A Pabreza,
    • B B Wolfe,
    • and K J Kellar
    A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment. Mol Pharmacol January 1992 41:31-37
  6. Article:
    • Bryan Goodwin,
    • Ecushla Hodgson,
    • and Christopher Liddle
    The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module Mol Pharmacol December 1, 1999 56:1329-1339
    • S Pippig,
    • S Andexinger,
    • and M J Lohse
    Sequestration and recycling of beta 2-adrenergic receptors permit receptor resensitization. Mol Pharmacol April 1995 47:666-676
  8. Article:
    • Gareth J. Inman,
    • Francisco J. Nicolás,
    • James F. Callahan,
    • John D. Harling,
    • Laramie M. Gaster,
    • Alastair D. Reith,
    • Nicholas J. Laping,
    • and Caroline S. Hill
    SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7 Mol Pharmacol July 1, 2002 62:65-74; doi:10.1124/mol.62.1.65
  9. Article:
    • Tomas Barkhem,
    • Bo Carlsson,
    • Yvonne Nilsson,
    • Eva Enmark,
    • Jan-Åke Gustafsson,
    • and Stefan Nilsson
    Differential Response of Estrogen Receptor α and Estrogen Receptor β to Partial Estrogen Agonists/Antagonists Mol Pharmacol July 1, 1998 54:105-112
  10. Article:
    • Yunhai Cui,
    • Jörg König,
    • Ulrike Buchholz,
    • Herbert Spring,
    • Inka Leier,
    • and Dietrich Keppler
    Drug Resistance and ATP-Dependent Conjugate Transport Mediated by the Apical Multidrug Resistance Protein, MRP2, Permanently Expressed in Human and Canine Cells Mol Pharmacol May 1, 1999 55:929-937
  11. Article:
    • Jodi M. Maglich,
    • Catherine M. Stoltz,
    • Bryan Goodwin,
    • Diane Hawkins-Brown,
    • John T. Moore,
    • and Steven A. Kliewer
    Nuclear Pregnane X Receptor and Constitutive Androstane Receptor Regulate Overlapping but Distinct Sets of Genes Involved in Xenobiotic Detoxification Mol Pharmacol September 1, 2002 62:638-646; doi:10.1124/mol.62.3.638
  12. Article:
    • Luc Ménard,
    • Stephen S. G. Ferguson,
    • Jie Zhang,
    • Fang-Tsyr Lin,
    • Robert J. Lefkowitz,
    • Marc G. Caron,
    • and Larry S. Barak
    Synergistic Regulation of β2-Adrenergic Receptor Sequestration: Intracellular Complement of β-Adrenergic Receptor Kinase and β-Arrestin Determine Kinetics of Internalization Mol Pharmacol May 1, 1997 51:800-808
    • W A Devane,
    • F A Dysarz, 3rd,
    • M R Johnson,
    • L S Melvin,
    • and A C Howlett
    Determination and characterization of a cannabinoid receptor in rat brain. Mol Pharmacol November 1988 34:605-613
    • Robert Fredriksson,
    • Malin C. Lagerström,
    • Lars-Gustav Lundin,
    • and Helgi B. Schiöth
    The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints Mol Pharmacol June 2003 63:1256-1272; doi:10.1124/mol.63.6.1256
    • R P Xiao,
    • X Ji,
    • and E G Lakatta
    Functional coupling of the beta 2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes. Mol Pharmacol February 1995 47:322-329
  16. Article:
    • Seok Ho Cha,
    • Takashi Sekine,
    • Jun-ichi Fukushima,
    • Yoshikatsu Kanai,
    • Yukari Kobayashi,
    • Tomoyuki Goya,
    • and Hitoshi Endou
    Identification and Characterization of Human Organic Anion Transporter 3 Expressing Predominantly in the Kidney Mol Pharmacol May 1, 2001 59:1277-1286
  17. Accelerated Communication:
    • Akiko Ueda,
    • Hisham K. Hamadeh,
    • Heather K. Webb,
    • Yukio Yamamoto,
    • Tatsuya Sueyoshi,
    • Cynthia A. Afshari,
    • Jürgen M. Lehmann,
    • and Masahiko Negishi
    Diverse Roles of the Nuclear Orphan Receptor CAR in Regulating Hepatic Genes in Response to Phenobarbital Mol Pharmacol January 1, 2002 61:1-6; doi:10.1124/mol.61.1.1
    • R A Nicholas,
    • W C Watt,
    • E R Lazarowski,
    • Q Li,
    • and K Harden
    Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor. Mol Pharmacol August 1996 50:224-229
    • R S Pollenz,
    • C A Sattler,
    • and A Poland
    The aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein show distinct subcellular localizations in Hepa 1c1c7 cells by immunofluorescence microscopy. Mol Pharmacol March 1994 45:428-438
    • C C Felder,
    • K E Joyce,
    • E M Briley,
    • J Mansouri,
    • K Mackie,
    • O Blond,
    • Y Lai,
    • A L Ma,
    • and R L Mitchell
    Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors. Mol Pharmacol September 1995 48:443-450
    • P Chidiac,
    • T E Hebert,
    • M Valiquette,
    • M Dennis,
    • and M Bouvier
    Inverse agonist activity of beta-adrenergic antagonists. Mol Pharmacol March 1994 45:490-499
  22. Article:
    • Kelly A. Berg,
    • Saul Maayani,
    • Joseph Goldfarb,
    • Clare Scaramellini,
    • Paul Leff,
    • and William P. Clarke
    Effector Pathway-Dependent Relative Efficacy at Serotonin Type 2A and 2C Receptors: Evidence for Agonist-Directed Trafficking of Receptor Stimulus Mol Pharmacol July 1, 1998 54:94-104
    • L Counillon,
    • W Scholz,
    • H J Lang,
    • and J Pouysségur
    Pharmacological characterization of stably transfected Na+/H+ antiporter isoforms using amiloride analogs and a new inhibitor exhibiting anti-ischemic properties. Mol Pharmacol November 1993 44:1041-1045
    • E G Schuetz,
    • W T Beck,
    • and J D Schuetz
    Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Mol Pharmacol February 1996 49:311-318
  25. MINIREVIEW:
    • Trudy A. Kohout and
    • Robert J. Lefkowitz
    Regulation of G Protein-Coupled Receptor Kinases and Arrestins During Receptor Desensitization Mol Pharmacol January 1, 2003 63:9-18; doi:10.1124/mol.63.1.9
  26. MINIREVIEW:
    • Alex Toker
    Protein Kinases as Mediators of Phosphoinositide 3-Kinase Signaling Mol Pharmacol April 1, 2000 57:652-658
    • K Raynor,
    • H Kong,
    • Y Chen,
    • K Yasuda,
    • L Yu,
    • G I Bell,
    • and T Reisine
    Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors. Mol Pharmacol February 1994 45:330-334
  28. Accelerated Communication:
    • Christian Behl,
    • Thomas Skutella,
    • Frank Lezoualc’H,
    • Anke Post,
    • Martina Widmann,
    • Christopher J. Newton,
    • and Florian Holsboer
    Neuroprotection against Oxidative Stress by Estrogens: Structure-Activity Relationship Mol Pharmacol April 1, 1997 51:535-541
  29. Article:
    • Jianhong Luo,
    • Yuehua Wang,
    • Robert P. Yasuda,
    • Anthone W. Dunah,
    • and Barry B. Wolfe
    The Majority of N-Methyl-d-Aspartate Receptor Complexes in Adult Rat Cerebral Cortex Contain at Least Three Different Subunits (NR1/NR2A/NR2B) Mol Pharmacol January 1, 1997 51:79-86
    • M G Kazanietz,
    • L B Areces,
    • A Bahador,
    • H Mischak,
    • J Goodnight,
    • J F Mushinski,
    • and P M Blumberg
    Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent protein kinase C isozymes. Mol Pharmacol August 1993 44:298-307
  31. Accelerated Communication:
    • Keiko Shimamoto,
    • Bruno Lebrun,
    • Yoshimi Yasuda-Kamatani,
    • Masahiro Sakaitani,
    • Yasushi Shigeri,
    • Noboru Yumoto,
    • and Terumi Nakajima
    dl-threo-β-Benzyloxyaspartate, A Potent Blocker of Excitatory Amino Acid Transporters Mol Pharmacol February 1, 1998 53:195-201
    • Eduardo R. Lazarowski,
    • Richard C. Boucher,
    • and T. Kendall Harden
    Mechanisms of Release of Nucleotides and Integration of Their Action as P2X- and P2Y-Receptor Activating Molecules Mol Pharmacol October 2003 64:785-795; doi:10.1124/mol.64.4.785
  33. Article:
    • N. J. Laping,
    • E. Grygielko,
    • A. Mathur,
    • S. Butter,
    • J. Bomberger,
    • C. Tweed,
    • W. Martin,
    • J. Fornwald,
    • R. Lehr,
    • J. Harling,
    • L. Gaster,
    • J. F. Callahan,
    • and B. A. Olson
    Inhibition of Transforming Growth Factor (TGF)-β1–Induced Extracellular Matrix with a Novel Inhibitor of the TGF-β Type I Receptor Kinase Activity: SB-431542 Mol Pharmacol July 1, 2002 62:58-64; doi:10.1124/mol.62.1.58
  34. Accelerated Communication:
    • Lei Zhang,
    • Mark J. Dresser,
    • Andrew T. Gray,
    • Spencer C. Yost,
    • Shigeyuki Terashita,
    • and Kathleen M. Giacomini
    Cloning and Functional Expression of a Human Liver Organic Cation Transporter Mol Pharmacol June 1, 1997 51:913-921
    • X Peng,
    • V Gerzanich,
    • R Anand,
    • P J Whiting,
    • and J Lindstrom
    Nicotine-induced increase in neuronal nicotinic receptors results from a decrease in the rate of receptor turnover. Mol Pharmacol September 1994 46:523-530
    • C F Bennett,
    • M Y Chiang,
    • H Chan,
    • J E Shoemaker,
    • and C K Mirabelli
    Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides. Mol Pharmacol June 1992 41:1023-1033
  37. Accelerated Communication:
    • Larry S. Barak,
    • Stephen S. G. Ferguson,
    • Jie Zhang,
    • Christopher Martenson,
    • Tobias Meyer,
    • and Marc G. Caron
    Internal Trafficking and Surface Mobility of a Functionally Intact β2-Adrenergic Receptor-Green Fluorescent Protein Conjugate Mol Pharmacol February 1, 1997 51:177-184
    • Y Chen,
    • A Mestek,
    • J Liu,
    • J A Hurley,
    • and L Yu
    Molecular cloning and functional expression of a mu-opioid receptor from rat brain. Mol Pharmacol July 1993 44:8-12
    • B Brüne and
    • V Ullrich
    Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase. Mol Pharmacol October 1987 32:497-504
  40. Article:
    • Tomas Cihlar,
    • Deborah C. Lin,
    • John B. Pritchard,
    • Michael D. Fuller,
    • Dirk B. Mendel,
    • and Douglas H. Sweet
    The Antiviral Nucleotide Analogs Cidofovir and Adefovir Are Novel Substrates for Human and Rat Renal Organic Anion Transporter 1 Mol Pharmacol September 1, 1999 56:570-580
  41. MINIREVIEW:
    • Tammy M. Seasholtz,
    • Mousumi Majumdar,
    • and Joan Heller Brown
    MINIREVIEW: Rho as a Mediator of G Protein-Coupled Receptor Signaling Mol Pharmacol June 1, 1999 55:949-956
  42. Article:
    • Christian P. Strassburg,
    • Karl Oldhafer,
    • Michael P. Manns,
    • and Robert H. Tukey
    Differential Expression of the UGT1A Locus in Human Liver, Biliary, and Gastric Tissue: Identification ofUGT1A7 and UGT1A10 Transcripts in Extrahepatic Tissue Mol Pharmacol August 1, 1997 52:212-220
    • A M Garland,
    • E F Grady,
    • M Lovett,
    • S R Vigna,
    • M M Frucht,
    • J E Krause,
    • and N W Bunnett
    Mechanisms of desensitization and resensitization of G protein-coupled neurokinin1 and neurokinin2 receptors. Mol Pharmacol March 1996 49:438-446
  44. MINIREVIEW:
    • Juan A. Ballesteros,
    • Lei Shi,
    • and Jonathan A. Javitch
    Structural Mimicry in G Protein-Coupled Receptors: Implications of the High-Resolution Structure of Rhodopsin for Structure-Function Analysis of Rhodopsin-Like Receptors Mol Pharmacol July 1, 2001 60:1-19
  45. Article:
    • Tomoko Hirohashi,
    • Hiroshi Suzuki,
    • Kousei Ito,
    • Kotaro Ogawa,
    • Kazuhiko Kume,
    • Takao Shimizu,
    • and Yuichi Sugiyama
    Hepatic Expression of Multidrug Resistance-Associated Protein-Like Proteins Maintained in Eisai Hyperbilirubinemic Rats Mol Pharmacol June 1, 1998 53:1068-1075
    • A Schrammel,
    • S Behrends,
    • K Schmidt,
    • D Koesling,
    • and B Mayer
    Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase. Mol Pharmacol July 1996 50:1-5
    • D J Snyders and
    • A Chaudhary
    High affinity open channel block by dofetilide of HERG expressed in a human cell line. Mol Pharmacol June 1996 49:949-955
    • W Zhou,
    • C Flanagan,
    • J A Ballesteros,
    • K Konvicka,
    • J S Davidson,
    • H Weinstein,
    • R P Millar,
    • and S C Sealfon
    A reciprocal mutation supports helix 2 and helix 7 proximity in the gonadotropin-releasing hormone receptor. Mol Pharmacol February 1994 45:165-170
  49. Article:
    • Donglin Bai,
    • Guoyun Zhu,
    • Peter Pennefather,
    • Michael F. Jackson,
    • John F. MacDonald,
    • and Beverley A. Orser
    Distinct Functional and Pharmacological Properties of Tonic and Quantal Inhibitory Postsynaptic Currents Mediated by γ-Aminobutyric AcidA Receptors in Hippocampal Neurons Mol Pharmacol April 1, 2001 59:814-824
    • K M Partin,
    • D K Patneau,
    • and M L Mayer
    Cyclothiazide differentially modulates desensitization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor splice variants. Mol Pharmacol July 1994 46:129-138

Last updated 11/09/2009 11:19:19

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