Most-Read Articles during September 2009 -- updated monthly.

Most-read rankings are recalculated at the beginning of the month and are based on full-text and pdf views.

  1. Article:
    • David Fenard,
    • Gerard Lambeau,
    • Thomas Maurin,
    • Jean-Claude Lefebvre,
    • and Alain Doglio
    A Peptide Derived from Bee Venom-Secreted Phospholipase A2 Inhibits Replication of T-Cell Tropic HIV-1 Strains via Interaction with the CXCR4 Chemokine Receptor Mol Pharmacol August 1, 2001 60:341-347
  2. Article:
    • Mandy Woods,
    • Jane A. Mitchell,
    • Elizabeth G. Wood,
    • Stewart Barker,
    • Nicholas R. Walcot,
    • Gareth M. Rees,
    • and Timothy D. Warner
    Endothelin-1 Is Induced by Cytokines in Human Vascular Smooth Muscle Cells: Evidence for Intracellular Endothelin-Converting Enzyme Mol Pharmacol May 1, 1999 55:902-909
  3. MINIREVIEW:
    • Qingdong Ke and
    • Max Costa
    Hypoxia-Inducible Factor-1 (HIF-1) Mol Pharmacol November 2006 70:1469-1480; published ahead of print August 3, 2006, doi:10.1124/mol.106.027029
  4. Article:
    • Sang Mi Shin,
    • Il Je Cho,
    • and Sang Geon Kim
    Resveratrol protects mitochondria against oxidative stress through AMPK-mediated GSK3β inhibition downstream of poly(ADP-ribose)polymerase-LKB1 pathway Mol Pharmacol ; published ahead of print July 20, 2009, doi:10.1124/mol.109.058479
  5. MINIREVIEWS:
    • Petrine Wellendorph,
    • Lars Dan Johansen,
    • and Hans Bräuner-Osborne
    Molecular Pharmacology of Promiscuous Seven Transmembrane Receptors Sensing Organic Nutrients Mol Pharmacol September 2009 76:453-465; published ahead of print June 1, 2009, doi:10.1124/mol.109.055244
  6. Article:
    • John A Allen,
    • Jiang Z Yu,
    • Rahul H Dave,
    • Anushree Bhatnagar,
    • Bryan L Roth,
    • and Mark M Rasenick
    Caveolin-1 and lipid microdomains regulate Gs trafficking and attenuate Gs/adenylyl cyclase signaling Mol Pharmacol ; published ahead of print August 20, 2009, doi:10.1124/mol.109.060160
  7. Article:
    • Lioubov I. Brueggemann,
    • Alexander R. Mackie,
    • Bharath K. Mani,
    • Leanne L. Cribbs,
    • and Kenneth L. Byron
    Differential Effects of Selective COX-2 Inhibitors on Vascular Smooth Muscle Ion Channels May Account for Differences in Cardiovascular Risk Profiles. Mol Pharmacol ; published ahead of print July 15, 2009, doi:10.1124/mol.109.057844
  8. Article:
    • Karl-Friedrich Deml,
    • Silke Beermann,
    • Detlef Neumann,
    • Andrea Strasser,
    • and Roland Seifert
    Interactions of Histamine H1-Receptor Agonists and Antagonists with the Human Histamine H4-Receptor Mol Pharmacol ; published ahead of print August 31, 2009, doi:10.1124/mol.109.058651
  9. MINIREVIEWS:
    • Joris Vriens,
    • Giovanni Appendino,
    • and Bernd Nilius
    Pharmacology of Vanilloid Transient Receptor Potential Cation Channels Mol Pharmacol June 2009 75:1262-1279; published ahead of print March 18, 2009, doi:10.1124/mol.109.055624
    • Graeme Milligan
    G Protein-Coupled Receptor Dimerization: Function and Ligand Pharmacology Mol Pharmacol July 2004 66:1-7; published ahead of print May 21, 2004, doi:10.1124/mol.104.000497
    • Robert Fredriksson,
    • Malin C. Lagerström,
    • Lars-Gustav Lundin,
    • and Helgi B. Schiöth
    The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints Mol Pharmacol June 2003 63:1256-1272; doi:10.1124/mol.63.6.1256
  12. Article:
    • Gareth J. Inman,
    • Francisco J. Nicolás,
    • James F. Callahan,
    • John D. Harling,
    • Laramie M. Gaster,
    • Alastair D. Reith,
    • Nicholas J. Laping,
    • and Caroline S. Hill
    SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7 Mol Pharmacol July 1, 2002 62:65-74; doi:10.1124/mol.62.1.65
  13. Article:
    • Laura Milan-Lobo,
    • Ingrid Gsandtner,
    • Erwin Gaubitzer,
    • Dominik Runzler,
    • Florian Buchmayer,
    • Gottfried Kohler,
    • Antonello Bonci,
    • Michael Freissmuth,
    • and Harald Sitte
    Subtype-specific Differences in CRF Receptor Complexes Detected by Fluorescence Spectroscopy Mol Pharmacol ; published ahead of print September 15, 2009, doi:10.1124/mol.109.059139
  14. Article:
    • Lijun Zhou,
    • Jingjing Zhang,
    • Qichen Fang,
    • Meilian Liu,
    • Xianling Liu,
    • Weiping Jia,
    • Lily Q. Dong,
    • and Feng Liu
    Autophagy-Mediated Insulin Receptor Down-Regulation Contributes to Endoplasmic Reticulum Stress-Induced Insulin Resistance Mol Pharmacol September 2009 76:596-603; published ahead of print June 18, 2009, doi:10.1124/mol.109.057067
  15. Article:
    • Qiang Li,
    • David L Bartlett,
    • Michael C Gorry,
    • Mark E O'Malley,
    • and Zong Sheng Guo
    Three Epigenetic Drugs Up-regulate Homeobox Gene Rhox5 in Cancer Cells through Overlapping and Distinct Molecular Mechanisms Mol Pharmacol ; published ahead of print August 13, 2009, doi:10.1124/mol.109.056291
  16. Article:
    • Susan Oldfield,
    • Jane M Hancock,
    • Angharad Mason,
    • Sally A Hobson,
    • David Wynick,
    • Eamonn Kelly,
    • Andrew D Randall,
    • and Neil V Marrion
    Receptor-mediated suppression of potassium currents requires co-localization within lipid rafts. Mol Pharmacol ; published ahead of print September 2, 2009, doi:10.1124/mol.109.058008
  17. EDITOR'S NOTE:
    • P. Jeffrey Conn
    Molecular Pharmacology in the Postgenomic Era Mol Pharmacol January 2007 71:1-2; doi:10.1124/mol.71.1.1
  18. Article:
    • Susanne Reiner,
    • Nicole Ziegler,
    • Cathrine Leon,
    • Kristina Lorenz,
    • Kathrin von Hayn,
    • Christian Gachet,
    • Martin J Lohse,
    • and Carsten Hoffmann
    β-ARRESTIN-2 INTERACTION AND INTERNALIZATION OF THE HUMAN P2Y1-RECEPTOR ARE DEPENDENT ON C-TERMINAL PHOSPHORLAYTION SITES Mol Pharmacol ; published ahead of print September 9, 2009, doi:10.1124/mol.109.060467
  19. Article:
    • Bokyung Sung,
    • Manoj K. Pandey,
    • and Bharat B. Aggarwal
    Fisetin, an Inhibitor of Cyclin-Dependent Kinase 6, Down-Regulates Nuclear Factor-κB-Regulated Cell Proliferation, Antiapoptotic and Metastatic Gene Products through the Suppression of TAK-1 and Receptor-Interacting Protein-Regulated IκBα Kinase Activation Mol Pharmacol June 2007 71:1703-1714; published ahead of print March 26, 2007, doi:10.1124/mol.107.034512
  20. MINIREVIEW:
    • Christopher A. Johnston and
    • David P. Siderovski
    Receptor-Mediated Activation of Heterotrimeric G-Proteins: Current Structural Insights Mol Pharmacol August 2007 72:219-230; published ahead of print April 12, 2007, doi:10.1124/mol.107.034348
  21. Article:
    • Sergio Anguissola,
    • Barbara Kohler,
    • Robert O'Byrne,
    • Heiko Dussmann,
    • Mary D Cannon,
    • Frank E Murray,
    • Caoimhin G Concannon,
    • Markus Rehm,
    • Donat Kogel,
    • and Jochen H.M. Prehn
    Bid and Calpains cooperate to Trigger Oxaliplatin-induced Apoptosis of Cervical Carcinoma HeLa Cells Mol Pharmacol ; published ahead of print August 27, 2009, doi:10.1124/mol.109.058156
  22. Minireview:
    • Carmen W Dessauer
    Adenylyl Cyclase-AKAP Complexes: The Next Dimension in cAMP Signaling Mol Pharmacol ; published ahead of print August 14, 2009, doi:10.1124/mol.109.059345
  23. Article:
    • Shary N Shelton,
    • Mary E Shawgo,
    • Shawna B Comer,
    • Yuanming Lu,
    • Alison C Donnelly,
    • Kristen Szabla,
    • Mehmet Tanol,
    • George A Vielhauer,
    • Roger A Rajewski,
    • Robert L Matts,
    • Brian S J Blagg,
    • and John D Robertson
    KU135, a Novel Novobiocin-derived C-terminal Inhibitor of Hsp90, Exerts Potent Antiproliferative Effects in Human Leukemic Cells Mol Pharmacol ; published ahead of print September 9, 2009, doi:10.1124/mol.109.058545
  24. Article:
    • Serife Cankurtaran-Sayar,
    • Kemal Sayar,
    • and Mehmet Ugur
    P2X7 RECEPTOR ACTIVATES MULTIPLE SELECTIVE DYE PERMEATION PATHWAYS IN RAW 264.7 AND HEK-293 CELLS Mol Pharmacol ; published ahead of print September 11, 2009, doi:10.1124/mol.109.059923
  25. Article:
    • Tengis S Pavlov,
    • Vladislav Levchenko,
    • Alexey V Karpushev,
    • Alain Vandewalle,
    • and Alexander Staruschenko
    PPARγ antagonists decrease Na+ transport via the epithelial Na+ channel (ENaC) Mol Pharmacol ; published ahead of print September 14, 2009, doi:10.1124/mol.109.056911
  26. MINIREVIEW:
    • David L. DeWitt
    Cox-2-Selective Inhibitors: The New Super Aspirins Mol Pharmacol April 1, 1999 55:625-631
  27. Article:
    • Lisa A Vuchak,
    • Oxana Tsygankova,
    • Gregory Prendergast,
    • and Judy Meinkoth
    PKA and B-Raf mediate ERK activation by TSH Mol Pharmacol ; published ahead of print August 31, 2009, doi:10.1124/mol.109.060129
  28. Article:
    • Toshimasa Ishizaki,
    • Masayoshi Uehata,
    • Ichiro Tamechika,
    • Jeongsin Keel,
    • Kimiko Nonomura,
    • Midori Maekawa,
    • and Shuh Narumiya
    Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases Mol Pharmacol May 1, 2000 57:976-983
  29. Article:
    • Ligong Chen,
    • Gregory D Salinas,
    • and Xiaohua Li
    Regulation of Serotonin 1B Receptor by Glycogen Synthase Kinase-3 Mol Pharmacol ; published ahead of print September 9, 2009, doi:10.1124/mol.109.056994
  30. Article:
    • Jennifer L. Holmes and
    • Richard S. Pollenz
    Determination of Aryl Hydrocarbon Receptor Nuclear Translocator Protein Concentration and Subcellular Localization in Hepatic and Nonhepatic Cell Culture Lines: Development of Quantitative Western Blotting Protocols for Calculation of Aryl Hydrocarbon Receptor and Aryl Hydrocarbon Receptor Nuclear Translocator Protein in Total Cell Lysates Mol Pharmacol August 1, 1997 52:202-211
  31. Article:
    • Jyrki J. Eloranta,
    • Christian Hiller,
    • Stephanie Hausler,
    • Bruno Stieger,
    • and Gerd A. Kullak-Ublick
    Vitamin D3 and its Nuclear Receptor Increase the Expression and Activity of the Human Proton-Coupled Folate Transporter Mol Pharmacol ; published ahead of print August 7, 2009, doi:10.1124/mol.109.055392
  32. Article:
    • Hany A. Omar,
    • Aaron M. Sargeant,
    • Jing-Ru Weng,
    • Dasheng Wang,
    • Samuel K. Kulp,
    • Tushar Patel,
    • and Ching-Shih Chen
    Targeting of the Akt-NF-κB Signaling Network by OSU-A9, a Novel Indole-3-Carbinol Derivative, in a Mouse Model of Hepatocellular Carcinoma Mol Pharmacol ; published ahead of print August 25, 2009, doi:10.1124/mol.109.058180
  33. CENTENNIAL PERSPECTIVE:
    • David J. Waxman and
    • Minita G. Holloway
    Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes Mol Pharmacol August 2009 76:215-228; published ahead of print May 29, 2009, doi:10.1124/mol.109.056705
  34. Article:
    • Andreas Zeller,
    • M. Verena Wenzl,
    • Matteo Beretta,
    • Heike Stessel,
    • Michael Russwurm,
    • Doris Koesling,
    • Kurt Schmidt,
    • and Bernd Mayer
    Mechanisms underlying activation of soluble guanylate cyclase by the HNO donor Angeli's Salt Mol Pharmacol ; published ahead of print August 31, 2009, doi:10.1124/mol.109.059915
  35. Article:
    • Pari Malherbe,
    • Edilio Borroni,
    • Emmanuel Pinard,
    • Joseph G. Wettstein,
    • and Frédéric Knoflach
    Biochemical and Electrophysiological Characterization of Almorexant, a Dual Orexin 1 Receptor (OX1)/Orexin 2 Receptor (OX2) Antagonist: Comparison with Selective OX1 and OX2 Antagonists Mol Pharmacol September 2009 76:618-631; published ahead of print June 19, 2009, doi:10.1124/mol.109.055152
  36. Article:
    • Peter H Bui and
    • Oliver Hankinson
    FUNCTIONAL CHARACTERIZATION OF HUMAN CYTOCHROME P450 2S1 USING A SYNTHETIC GENE-EXPRESSED PROTEIN IN E. coli Mol Pharmacol ; published ahead of print August 27, 2009, doi:10.1124/mol.109.057752
    • Ya-Jen Chang,
    • Michael J. Holtzman,
    • and Ching-Chow Chen
    Differential Role of Janus Family Kinases (JAKs) in Interferon-γ–Induced Lung Epithelial ICAM-1 Expression: Involving Protein Interactions between JAKs, Phospholipase Cγ, c-Src, and STAT1 Mol Pharmacol March 2004 65:589-598; doi:10.1124/mol.65.3.589
  38. Article:
    • L. Michelle Lewis,
    • Gautam Bhave,
    • Brian A. Chauder,
    • Sreedatta Banerjee,
    • Katherina A. Lornsen,
    • Rey Redha,
    • Katherine Fallen,
    • Craig W. Lindsley,
    • C. David Weaver,
    • and Jerod S. Denton
    High-throughput screening reveals a small-molecule inhibitor of ROMK and Kir7.1 Mol Pharmacol ; published ahead of print August 25, 2009, doi:10.1124/mol.109.059840
  39. Article:
    • Joo-Yun Byun,
    • Min-Jung Kim,
    • Da-Young Eum,
    • Chang-Hwan Yoon,
    • Woo-Duck Seo,
    • Ki Hun Park,
    • Jin-Won Hyun,
    • Yun-Sil Lee,
    • Jae-Sung Lee,
    • Moon-Young Yoon,
    • and Su-Jae Lee
    Reactive oxygen species-dependent activation of Bax and PARP-1 is required for mitochondrial cell death induced by triterpenoid pristimerin in human cervical cancer cells Mol Pharmacol ; published ahead of print July 2, 2009, doi:10.1124/mol.109.056259
  40. Article:
    • Ping-Hui Tseng,
    • Yu-Chieh Wang,
    • Shu-Chuan Weng,
    • Jing-Ru Weng,
    • Chang-Shi Chen,
    • Robert W. Brueggemeier,
    • Charles L. Shapiro,
    • Ching-Yu Chen,
    • Sandra E. Dunn,
    • Michael Pollak,
    • and Ching-Shih Chen
    Overcoming Trastuzumab Resistance in HER2-Overexpressing Breast Cancer Cells by Using a Novel Celecoxib-Derived Phosphoinositide-Dependent Kinase-1 Inhibitor Mol Pharmacol November 2006 70:1534-1541; published ahead of print August 3, 2006, doi:10.1124/mol.106.023911
  41. MINIREVIEW:
    • Heather A. Carlson and
    • J. Andrew McCammon
    Accommodating Protein Flexibility in Computational Drug Design , Mol Pharmacol February 1, 2000 57:213-218
  42. Article:
    • Lifen Zhang,
    • William M. Doyon,
    • Jeremy J. Clark,
    • Paul E. M. Phillips,
    • and John A. Dani
    Controls of Tonic and Phasic Dopamine Transmission in the Dorsal and Ventral Striatum Mol Pharmacol August 2009 76:396-404; published ahead of print May 21, 2009, doi:10.1124/mol.109.056317
    • Ramin Raouf,
    • Yassar Chakfe,
    • Dominique Blais,
    • Audrey Speelman,
    • Eric Boué-Grabot,
    • Duncan Henderson,
    • and Philippe Séguéla
    Selective Knock-Down of P2X7 ATP Receptor Function by Dominant-Negative Subunits Mol Pharmacol March 2004 65:646-654; doi:10.1124/mol.65.3.646
  44. Article:
    • Adam C. Errington,
    • Thomas Stöhr,
    • Cara Heers,
    • and George Lees
    The Investigational Anticonvulsant Lacosamide Selectively Enhances Slow Inactivation of Voltage-Gated Sodium Channels Mol Pharmacol January 2008 73:157-169; published ahead of print October 16, 2007, doi:10.1124/mol.107.039867
  45. Article:
    • Hiroshi Aoki,
    • Yasunari Takada,
    • Seiji Kondo,
    • Raymond Sawaya,
    • Bharat B. Aggarwal,
    • and Yasuko Kondo
    Evidence That Curcumin Suppresses the Growth of Malignant Gliomas in Vitro and in Vivo through Induction of Autophagy: Role of Akt and Extracellular Signal-Regulated Kinase Signaling Pathways Mol Pharmacol July 2007 72:29-39; published ahead of print March 29, 2007, doi:10.1124/mol.106.033167
  46. MINIREVIEWS:
    • Sun-Young Ahn and
    • Sanjay K. Nigam
    Toward a Systems Level Understanding of Organic Anion and Other Multispecific Drug Transporters: A Remote Sensing and Signaling Hypothesis Mol Pharmacol September 2009 76:481-490; published ahead of print June 10, 2009, doi:10.1124/mol.109.056564
  47. Perspective:
    • Mark S. Shapiro
    An ion channel hypothesis to explain divergent cardiovascular safety of COX-2 inhibitors: the answer to a hotly-debated puzzle? (Relates to article by Brueggemann, et al., Fast Forward 15 July 2009) Mol Pharmacol ; published ahead of print August 4, 2009, doi:10.1124/mol.109.059683
  48. Article:
    • Aditi Pandya Martin,
    • Margaret A. Park,
    • Clint Mitchell,
    • Teneille Walker,
    • Mohamed Rahmani,
    • Andrew Thorburn,
    • Dieter Häussinger,
    • Roland Reinehr,
    • Steven Grant,
    • and Paul Dent
    BCL-2 Family Inhibitors Enhance Histone Deacetylase Inhibitor and Sorafenib Lethality via Autophagy and Overcome Blockade of the Extrinsic Pathway to Facilitate Killing Mol Pharmacol August 2009 76:327-341; published ahead of print May 29, 2009, doi:10.1124/mol.109.056309
  49. Article:
    • Sridharan soundararajan,
    • Li Wang,
    • vijayalakshmi sridharan,
    • Weiwei Chen,
    • Nigel Courtenay-Luck,
    • David Jones,
    • Eleanor K Spicer,
    • and Daniel J Fernandes
    Plasma Membrane Nucleolin is a Receptor for the Anticancer Aptamer AS1411 in MV4-11 Leukemia Cells Mol Pharmacol ; published ahead of print August 5, 2009, doi:10.1124/mol.109.055947
  50. Article:
    • G. Scapagnini,
    • R. Foresti,
    • V. Calabrese,
    • A. M. Giuffrida Stella,
    • C. J. Green,
    • and R. Motterlini
    Caffeic Acid Phenethyl Ester and Curcumin: A Novel Class of Heme Oxygenase-1 Inducers Mol Pharmacol March 1, 2002 61:554-561; doi:10.1124/mol.61.3.554

Last updated 11/09/2009 11:11:30

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