Abstract
Evidence is presented to show that, assuming other factors constant, the variation in biological response in a set of congeneric drugs can be represented as a function of the partition coefficient. The form of this function is the same as the form of the normal distribution. Building upon this foundation, one can use substituent constants to quantitatively separate the hydrophobic bonding and the electronic and steric effects of substituents.
ACKNOWLEDGMENT This work was supported by Research Grant GM-07492 from the National Institutes of Health.
- Copyright ©, 1965, by Academic Press Inc.
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