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Research ArticleArticles

The Use of a Hydrophobic Bonding Constant for Structure-Activity Correlations

CORWIN HANSCH, A. RUTH STEWARD, JUNKICHI IWASA and EDNA W. DEUTSCH
Molecular Pharmacology November 1965, 1 (3) 205-213; DOI: https://doi.org/10.1124/mol.1.3.205
CORWIN HANSCH
Department of Chemistry, Pomona College, Claremont, California
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A. RUTH STEWARD
Department of Chemistry, Pomona College, Claremont, California
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JUNKICHI IWASA
Department of Chemistry, Pomona College, Claremont, California
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EDNA W. DEUTSCH
Department of Chemistry, Pomona College, Claremont, California
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Abstract

Evidence is presented to show that, assuming other factors constant, the variation in biological response in a set of congeneric drugs can be represented as a function of the partition coefficient. The form of this function is the same as the form of the normal distribution. Building upon this foundation, one can use substituent constants to quantitatively separate the hydrophobic bonding and the electronic and steric effects of substituents.

ACKNOWLEDGMENT This work was supported by Research Grant GM-07492 from the National Institutes of Health.

  • Copyright ©, 1965, by Academic Press Inc.

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Molecular Pharmacology
Vol. 1, Issue 3
1 Nov 1965
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Research ArticleArticles

The Use of a Hydrophobic Bonding Constant for Structure-Activity Correlations

CORWIN HANSCH, A. RUTH STEWARD, JUNKICHI IWASA and EDNA W. DEUTSCH
Molecular Pharmacology November 1, 1965, 1 (3) 205-213; DOI: https://doi.org/10.1124/mol.1.3.205

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Research ArticleArticles

The Use of a Hydrophobic Bonding Constant for Structure-Activity Correlations

CORWIN HANSCH, A. RUTH STEWARD, JUNKICHI IWASA and EDNA W. DEUTSCH
Molecular Pharmacology November 1, 1965, 1 (3) 205-213; DOI: https://doi.org/10.1124/mol.1.3.205
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