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Molecular Pharmacology

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Research ArticleArticle

Metabolism of Trichloroethylene in Liver Microsomes

I. Characteristics of the Reaction

KENNETH C. LEIBMAN
Molecular Pharmacology November 1965, 1 (3) 239-246;
KENNETH C. LEIBMAN
Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida
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This article has a correction. Please see:

  • Metabolism of Trichloroethylene in Liver Microsomes - June 01, 1966

Abstract

The conversion of trichloroethylene to chloral hydrate was shown to take place in liver microsomes of rats, rabbits, and dogs, in a reaction requiring NADPH and oxygen. A stable, lyophilized preparation of microsomal and soluble fractions of liver homogenates in Tris buffer was used, from which a fraction could be obtained which resembled fresh microsomes in behavior. The effects of a number of activators and inhibitors of the enzyme system are described.

ACKNOWLEDGMENTS It is a pleasure to acknowledge the excellent technical assistance of Miss Elsa Ortiz. This work was supported in part by U.S. Public Health Service Research Grant No. OH-00124.

  • Copyright ©, 1965, by Academic Press Inc.

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Molecular Pharmacology
Vol. 1, Issue 3
1 Nov 1965
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Research ArticleArticle

Metabolism of Trichloroethylene in Liver Microsomes

KENNETH C. LEIBMAN
Molecular Pharmacology November 1, 1965, 1 (3) 239-246;

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Research ArticleArticle

Metabolism of Trichloroethylene in Liver Microsomes

KENNETH C. LEIBMAN
Molecular Pharmacology November 1, 1965, 1 (3) 239-246;
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