Abstract
A study of the conformation of neuroleptic durgs by X-ray diffraction and simple conformational calculations has revealed some relationships among the relative arrangements of possible pharmacodynamic groups for these substances. A hydrogen bond donor at an appropriate distance from the basic nitrogen common to most neuroleptics often results in an enhancement of activity.
ACKNOWLEDGMENTS I am much indebted to Dr. P. A. J. Janssen and Dr. J. Tollenaere for stimulating discussions. I also thank Professor M. Van Meerssche for his interest in this work.
- Copyright ©, 1974, by Academic Press, Inc.
MolPharm articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.