Table of Contents

Articles

• 

  Open Access

  Eribulin Activates the cGAS-STING Pathway via the Cytoplasmic Accumulation of Mitochondrial DNA

  Charles S. Fermaintt, Leila Takahashi-Ruiz, Huiyun Liang, Susan L. Mooberry and April L. Risinger

  Molecular Pharmacology October 2021, 100 (4) 309-318; DOI: https://doi.org/10.1124/molpharm.121.000297
• Open Access

  Acylation of the Incretin Peptide Exendin-4 Directly Impacts Glucagon-Like Peptide-1 Receptor Signaling and Trafficking

  Maria Lucey, Tanyel Ashik, Amaara Marzook, Yifan Wang, Joëlle Goulding, Atsuro Oishi, Johannes Broichhagen, David J. Hodson, James Minnion, Yuval Elani, Ralf Jockers, Stephen J. Briddon, Stephen R. Bloom, Alejandra Tomas and Ben Jones

  Molecular Pharmacology October 2021, 100 (4) 319-334; DOI: https://doi.org/10.1124/molpharm.121.000270
• Open Access

  CPL207280, a Novel G Protein–Coupled Receptor 40/Free Fatty Acid Receptor 1–Specific Agonist, Shows a Favorable Safety Profile and Exerts Antidiabetic Effects in Type 2 Diabetic Animals

  Katarzyna Bazydlo-Guzenda, Pawel Buda, Mikolaj Matloka, Mateusz Mach, Filip Stelmach, Radoslaw Dzida, Damian Smuga, Joanna Hucz-Kalitowska, Malgorzata Teska-Kaminska, Varvara Vialichka, Krzysztof Dubiel, Bozena Kaminska, Maciej Wieczorek and Jerzy Pieczykolan

  Molecular Pharmacology October 2021, 100 (4) 335-347; DOI: https://doi.org/10.1124/molpharm.121.000260
• You have access

  Current Understanding of Membrane Transporters as Regulators or Targets for Cisplatin-Induced Hearing Loss

  Kyle Z. Pasquariello, Jason M. Dey and Jason A. Sprowl

  Molecular Pharmacology October 2021, 100 (4) 348-355; DOI: https://doi.org/10.1124/molpharm.121.000274
• You have access

  ADP Ribosylation Factor 6 Promotes Contraction and Proliferation, Suppresses Apoptosis and Is Specifically Inhibited by NAV2729 in Prostate Stromal Cells

  Ruixiao Wang, Stephanie Schneider, Oliver T. Keppler, Bingsheng Li, Beata Rutz, Anna Ciotkowska, Christian G. Stief and Martin Hennenberg

  Molecular Pharmacology October 2021, 100 (4) 356-371; DOI: https://doi.org/10.1124/molpharm.121.000304
• You have access

  Pharmacological Characterization of the Imipridone Anticancer Drug ONC201 Reveals a Negative Allosteric Mechanism of Action at the D₂ Dopamine Receptor

  R. Benjamin Free, Caroline A. Cuoco, Bing Xie, Yoon Namkung, Varun V. Prabhu, Blair K.A. Willette, Marilyn M. Day, Marta Sanchez-Soto, J. Robert Lane, Stéphane A. Laporte, Lei Shi, Joshua E. Allen and David R. Sibley

  Molecular Pharmacology October 2021, 100 (4) 372-387; DOI: https://doi.org/10.1124/molpharm.121.000336
• You have access

  β₂-Adrenoceptor Agonists Promote Extracellular Signal-Regulated Kinase 1/2 Dephosphorylation in Human Airway Epithelial Cells by Canonical, cAMP-Driven Signaling Independently of β-Arrestin 2

  Omar Hamed, Radhika Joshi, Aubrey N. Michi, Cora Kooi and Mark A. Giembycz

  Molecular Pharmacology October 2021, 100 (4) 388-405; DOI: https://doi.org/10.1124/molpharm.121.000294
• You have access

  Membrane-Facilitated Receptor Access and Binding Mechanisms of Long-Acting β2-Adrenergic Receptor Agonists

  Christopher T. Szlenk, Jeevan B. GC and Senthil Natesan

  Molecular Pharmacology October 2021, 100 (4) 406-427; DOI: https://doi.org/10.1124/molpharm.121.000285