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Molecular Pharmacology

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Table of Contents

October 01, 2021; Volume 100,Issue 4

Articles

  • Eribulin Activates the cGAS-STING Pathway via the Cytoplasmic Accumulation of Mitochondrial DNA
    Open Access
    Eribulin Activates the cGAS-STING Pathway via the Cytoplasmic Accumulation of Mitochondrial DNA
    Charles S. Fermaintt, Leila Takahashi-Ruiz, Huiyun Liang, Susan L. Mooberry and April L. Risinger
    Molecular Pharmacology October 2021, 100 (4) 309-318; DOI: https://doi.org/10.1124/molpharm.121.000297
  • Open Access
    Acylation of the Incretin Peptide Exendin-4 Directly Impacts Glucagon-Like Peptide-1 Receptor Signaling and Trafficking
    Maria Lucey, Tanyel Ashik, Amaara Marzook, Yifan Wang, Joëlle Goulding, Atsuro Oishi, Johannes Broichhagen, David J. Hodson, James Minnion, Yuval Elani, Ralf Jockers, Stephen J. Briddon, Stephen R. Bloom, Alejandra Tomas and Ben Jones
    Molecular Pharmacology October 2021, 100 (4) 319-334; DOI: https://doi.org/10.1124/molpharm.121.000270
  • Open Access
    CPL207280, a Novel G Protein–Coupled Receptor 40/Free Fatty Acid Receptor 1–Specific Agonist, Shows a Favorable Safety Profile and Exerts Antidiabetic Effects in Type 2 Diabetic Animals
    Katarzyna Bazydlo-Guzenda, Pawel Buda, Mikolaj Matloka, Mateusz Mach, Filip Stelmach, Radoslaw Dzida, Damian Smuga, Joanna Hucz-Kalitowska, Malgorzata Teska-Kaminska, Varvara Vialichka, Krzysztof Dubiel, Bozena Kaminska, Maciej Wieczorek and Jerzy Pieczykolan
    Molecular Pharmacology October 2021, 100 (4) 335-347; DOI: https://doi.org/10.1124/molpharm.121.000260
  • You have access
    Current Understanding of Membrane Transporters as Regulators or Targets for Cisplatin-Induced Hearing Loss
    Kyle Z. Pasquariello, Jason M. Dey and Jason A. Sprowl
    Molecular Pharmacology October 2021, 100 (4) 348-355; DOI: https://doi.org/10.1124/molpharm.121.000274
  • You have access
    ADP Ribosylation Factor 6 Promotes Contraction and Proliferation, Suppresses Apoptosis and Is Specifically Inhibited by NAV2729 in Prostate Stromal Cells
    Ruixiao Wang, Stephanie Schneider, Oliver T. Keppler, Bingsheng Li, Beata Rutz, Anna Ciotkowska, Christian G. Stief and Martin Hennenberg
    Molecular Pharmacology October 2021, 100 (4) 356-371; DOI: https://doi.org/10.1124/molpharm.121.000304
  • You have access
    Pharmacological Characterization of the Imipridone Anticancer Drug ONC201 Reveals a Negative Allosteric Mechanism of Action at the D2 Dopamine Receptor
    R. Benjamin Free, Caroline A. Cuoco, Bing Xie, Yoon Namkung, Varun V. Prabhu, Blair K.A. Willette, Marilyn M. Day, Marta Sanchez-Soto, J. Robert Lane, Stéphane A. Laporte, Lei Shi, Joshua E. Allen and David R. Sibley
    Molecular Pharmacology October 2021, 100 (4) 372-387; DOI: https://doi.org/10.1124/molpharm.121.000336
  • You have access
    β2-Adrenoceptor Agonists Promote Extracellular Signal-Regulated Kinase 1/2 Dephosphorylation in Human Airway Epithelial Cells by Canonical, cAMP-Driven Signaling Independently of β-Arrestin 2
    Omar Hamed, Radhika Joshi, Aubrey N. Michi, Cora Kooi and Mark A. Giembycz
    Molecular Pharmacology October 2021, 100 (4) 388-405; DOI: https://doi.org/10.1124/molpharm.121.000294
  • You have access
    Membrane-Facilitated Receptor Access and Binding Mechanisms of Long-Acting β2-Adrenergic Receptor Agonists
    Christopher T. Szlenk, Jeevan B. GC and Senthil Natesan
    Molecular Pharmacology October 2021, 100 (4) 406-427; DOI: https://doi.org/10.1124/molpharm.121.000285
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In this issue

Molecular Pharmacology: 100 (4)
Molecular Pharmacology
Vol. 100, Issue 4
1 Oct 2021
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  • SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7
  • The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints
  • Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases
  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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