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Molecular Pharmacology

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Table of Contents

November 01, 2021; Volume 100,Issue 5

Emerging Concepts

  • You have access
    Membrane-Mediated Activity of Local Anesthetics
    Stephan L. Grage, Anke Culetto, Anne S. Ulrich and Stefan Weinschenk
    Molecular Pharmacology November 2021, 100 (5) 502-512; DOI: https://doi.org/10.1124/molpharm.121.000252

Articles

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    Metformin Prevents Hyperglycemia-Associated, Oxidative Stress-Induced Vascular Endothelial Dysfunction: Essential Role for the Orphan Nuclear Receptor Human Nuclear Receptor 4A1 (Nur77)
    Vivek Krishna Pulakazhi Venu, Mahmoud Saifeddine, Koichiro Mihara, Muniba Faiza, Evgueni Gorobets, Andrew J. Flewelling, Darren J. Derksen, Simon A. Hirota, Isra Marei, Dana Al-Majid, Majid Motahhary, Hong Ding, Chris R. Triggle and Morley D. Hollenberg
    Molecular Pharmacology November 2021, 100 (5) 428-455; DOI: https://doi.org/10.1124/molpharm.120.000148
  • Tacrine Induces Endoplasmic Reticulum–Stressed Apoptosis via Disrupting the Proper Assembly of Oligomeric Acetylcholinesterase in Cultured Neuronal Cells
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    Tacrine Induces Endoplasmic Reticulum–Stressed Apoptosis via Disrupting the Proper Assembly of Oligomeric Acetylcholinesterase in Cultured Neuronal Cells
    Etta Y.L. Liu, Shinghung Mak, Xiangpeng Kong, Yingjie Xia, Kenneth K.L. Kwan, Miranda L. Xu and Karl W.K. Tsim
    Molecular Pharmacology November 2021, 100 (5) 456-469; DOI: https://doi.org/10.1124/molpharm.121.000269
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    Regulation of Adrenergic, Serotonin, and Dopamine Receptors to Inhibit Diabetic Retinopathy: Monotherapies versus Combination Therapies
    Timothy S. Kern, Yunpeng Du, Jie Tang, Chieh Allen Lee, Haitao Liu, Alyssa Dreffs, Henri Leinonen, David A. Antonetti and Krzysztof Palczewski
    Molecular Pharmacology November 2021, 100 (5) 470-479; DOI: https://doi.org/10.1124/molpharm.121.000278
  • You have access
    Construction and Characterization of CRISPR/Cas9 Knockout Rat Model of Carboxylesterase 2a Gene
    Jie Liu, Xuyang Shang, Shengbo Huang, Yuan Xu, Jian Lu, Yuanjin Zhang, Zongjun Liu and Xin Wang
    Molecular Pharmacology November 2021, 100 (5) 480-490; DOI: https://doi.org/10.1124/molpharm.121.000357
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    Therapeutic Neuroprotection by an Engineered Neurotrophin that Selectively Activates Tropomyosin Receptor Kinase (Trk) Family Neurotrophin Receptors but Not the p75 Neurotrophin Receptor
    Fouad Brahimi, Alba Galan, Sairey Siegel, Stephanie Szobota, Marinko V. Sarunic, Alan C. Foster and H. Uri Saragovi
    Molecular Pharmacology November 2021, 100 (5) 491-501; DOI: https://doi.org/10.1124/molpharm.121.000301
  • Open Access
    Unique Positive Cooperativity Between the β-Arrestin–Biased β-Blocker Carvedilol and a Small Molecule Positive Allosteric Modulator of the β2-Adrenergic Receptor
    Biswaranjan Pani, Seungkirl Ahn, Paula K. Rambarat, Shashank Vege, Alem W. Kahsai, Andrew Liu, Bruno N. Valan, Dean P. Staus, Tommaso Costa and Robert J. Lefkowitz
    Molecular Pharmacology November 2021, 100 (5) 513-525; DOI: https://doi.org/10.1124/molpharm.121.000363
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In this issue

Molecular Pharmacology: 100 (5)
Molecular Pharmacology
Vol. 100, Issue 5
1 Nov 2021
  • Table of Contents
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  • The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints
  • Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases
  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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