Table of Contents

Articles

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  Metformin Prevents Hyperglycemia-Associated, Oxidative Stress-Induced Vascular Endothelial Dysfunction: Essential Role for the Orphan Nuclear Receptor Human Nuclear Receptor 4A1 (Nur77)

  Vivek Krishna Pulakazhi Venu, Mahmoud Saifeddine, Koichiro Mihara, Muniba Faiza, Evgueni Gorobets, Andrew J. Flewelling, Darren J. Derksen, Simon A. Hirota, Isra Marei, Dana Al-Majid, Majid Motahhary, Hong Ding, Chris R. Triggle and Morley D. Hollenberg

  Molecular Pharmacology November 2021, 100 (5) 428-455; DOI: https://doi.org/10.1124/molpharm.120.000148
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  Tacrine Induces Endoplasmic Reticulum–Stressed Apoptosis via Disrupting the Proper Assembly of Oligomeric Acetylcholinesterase in Cultured Neuronal Cells

  Etta Y.L. Liu, Shinghung Mak, Xiangpeng Kong, Yingjie Xia, Kenneth K.L. Kwan, Miranda L. Xu and Karl W.K. Tsim

  Molecular Pharmacology November 2021, 100 (5) 456-469; DOI: https://doi.org/10.1124/molpharm.121.000269
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  Regulation of Adrenergic, Serotonin, and Dopamine Receptors to Inhibit Diabetic Retinopathy: Monotherapies versus Combination Therapies

  Timothy S. Kern, Yunpeng Du, Jie Tang, Chieh Allen Lee, Haitao Liu, Alyssa Dreffs, Henri Leinonen, David A. Antonetti and Krzysztof Palczewski

  Molecular Pharmacology November 2021, 100 (5) 470-479; DOI: https://doi.org/10.1124/molpharm.121.000278
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  Construction and Characterization of CRISPR/Cas9 Knockout Rat Model of Carboxylesterase 2a Gene

  Jie Liu, Xuyang Shang, Shengbo Huang, Yuan Xu, Jian Lu, Yuanjin Zhang, Zongjun Liu and Xin Wang

  Molecular Pharmacology November 2021, 100 (5) 480-490; DOI: https://doi.org/10.1124/molpharm.121.000357
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  Therapeutic Neuroprotection by an Engineered Neurotrophin that Selectively Activates Tropomyosin Receptor Kinase (Trk) Family Neurotrophin Receptors but Not the p75 Neurotrophin Receptor

  Fouad Brahimi, Alba Galan, Sairey Siegel, Stephanie Szobota, Marinko V. Sarunic, Alan C. Foster and H. Uri Saragovi

  Molecular Pharmacology November 2021, 100 (5) 491-501; DOI: https://doi.org/10.1124/molpharm.121.000301
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  Unique Positive Cooperativity Between the β-Arrestin–Biased β-Blocker Carvedilol and a Small Molecule Positive Allosteric Modulator of the β2-Adrenergic Receptor

  Biswaranjan Pani, Seungkirl Ahn, Paula K. Rambarat, Shashank Vege, Alem W. Kahsai, Andrew Liu, Bruno N. Valan, Dean P. Staus, Tommaso Costa and Robert J. Lefkowitz

  Molecular Pharmacology November 2021, 100 (5) 513-525; DOI: https://doi.org/10.1124/molpharm.121.000363