Molecular Pharmacology: 100 (6)

December 01, 2021; Volume 100,Issue 6

Minireview

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Decoding the Cardiac Actions of Protein Kinase D Isoforms
Susan F. Steinberg

Molecular Pharmacology December 2021, 100 (6) 558-567; DOI: https://doi.org/10.1124/molpharm.121.000341

Emerging Concepts

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Potential Use of Senolytics for Pharmacological Targeting of Precancerous Lesions
Tareq Saleh and Valerie J. Carpenter

Molecular Pharmacology December 2021, 100 (6) 580-587; DOI: https://doi.org/10.1124/molpharm.121.000361

Articles

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High-Content Single-Cell Förster Resonance Energy Transfer Imaging of Cultured Striatal Neurons Reveals Novel Cross-Talk in the Regulation of Nuclear Signaling by Protein Kinase A and Extracellular Signal-Regulated Kinase 1/2
Jace Jones-Tabah, Ryan D. Martin, Jason C. Tanny, Paul B.S. Clarke and Terence E. Hébert

Molecular Pharmacology December 2021, 100 (6) 526-539; DOI: https://doi.org/10.1124/molpharm.121.000290
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Characterization of VU0468554, a New Selective Inhibitor of Cardiac G Protein–Gated Inwardly Rectifying K⁺ Channels
Allison Anderson, Baovi N. Vo, Ezequiel Marron Fernandez de Velasco, Corey R. Hopkins, C. David Weaver and Kevin Wickman

Molecular Pharmacology December 2021, 100 (6) 540-547; DOI: https://doi.org/10.1124/molpharm.121.000311
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Remdesivir and EIDD-1931 Interact with Human Equilibrative Nucleoside Transporters 1 and 2: Implications for Reaching SARS-CoV-2 Viral Sanctuary Sites
Siennah R. Miller, Meghan E. McGrath, Kimberley M. Zorn, Sean Ekins, Stephen H. Wright and Nathan J. Cherrington

Molecular Pharmacology December 2021, 100 (6) 548-557; DOI: https://doi.org/10.1124/molpharm.121.000333
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β-Arrestin–Biased Allosteric Modulator Potentiates Carvedilol-Stimulated β Adrenergic Receptor Cardioprotection
Jialu Wang, Biswaranjan Pani, Ilhan Gokhan, Xinyu Xiong, Alem W. Kahsai, Haoran Jiang, Seungkirl Ahn, Robert J. Lefkowitz and Howard A. Rockman

Molecular Pharmacology December 2021, 100 (6) 568-579; DOI: https://doi.org/10.1124/molpharm.121.000359
Open Access
Naturally Occurring Mutations to Muscle-Type Creatine Kinase Impact Its Canonical and Pharmacological Activities in a Substrate-Dependent Manner In Vitro
Eric P. Mosher, Colten D. Eberhard and Namandjé N. Bumpus

Molecular Pharmacology December 2021, 100 (6) 588-596; DOI: https://doi.org/10.1124/molpharm.121.000348
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Identification of Key Amino Acids that Impact Organic Solute Transporter α/β (OSTα/β)
William A. Murphy, James J. Beaudoin, Tuomo Laitinen, Noora Sjöstedt, Melina M. Malinen, Henry Ho, Peter W. Swaan, Paavo Honkakoski and Kim L.R. Brouwer

Molecular Pharmacology December 2021, 100 (6) 599-608; DOI: https://doi.org/10.1124/molpharm.121.000345