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Review ArticleMinireview

Mechanisms to Repair Stalled Topoisomerase II-DNA Covalent Complexes

Rebecca L. Swan, Ian G. Cowell and Caroline A. Austin
Molecular Pharmacology January 2022, 101 (1) 24-32; DOI: https://doi.org/10.1124/molpharm.121.000374
Rebecca L. Swan
Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom
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Ian G. Cowell
Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom
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Caroline A. Austin
Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom
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Article Information

vol. 101 no. 1 24-32
DOI 
https://doi.org/10.1124/molpharm.121.000374
PubMed 
34689119

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received July 21, 2021
  • Accepted October 11, 2021
  • Published online December 17, 2021.

Article Versions

  • Earlier version (October 23, 2021 - 16:06).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2021 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Rebecca L. Swan,
  2. Ian G. Cowell, and
  3. Caroline A. Austin
  1. Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom
  1. Address correspondence to:
    Caroline A. Austin, Biosciences Institute, Newcastle University, Faculty of Medical Sciences, Newcastle upon Tyne, NE2 4HH, United Kingdom. E-mail:caroline.austin{at}ncl.ac.uk
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Molecular Pharmacology: 101 (1)
Molecular Pharmacology
Vol. 101, Issue 1
1 Jan 2022
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Review ArticleMinireview

Review of TOP2 Covalent Complex Repair Mechanisms

Rebecca L. Swan, Ian G. Cowell and Caroline A. Austin
Molecular Pharmacology January 1, 2022, 101 (1) 24-32; DOI: https://doi.org/10.1124/molpharm.121.000374

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Review ArticleMinireview

Review of TOP2 Covalent Complex Repair Mechanisms

Rebecca L. Swan, Ian G. Cowell and Caroline A. Austin
Molecular Pharmacology January 1, 2022, 101 (1) 24-32; DOI: https://doi.org/10.1124/molpharm.121.000374
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  • Article
    • Abstract
    • Introduction
    • DNA Topoisomerase II and TOP2 Poisons
    • Proteolytic Mechanisms
    • Tyrosyl DNA Phosphodiesterase 2 (TDP2)
    • Nucleolytic Mechanisms
    • Role of Post-Translational Modifications
    • Conclusion
    • Authorship Contributions
    • Footnotes
    • Abbreviations
    • References
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