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Research ArticleArticle

Structural Basis of the Negative Allosteric Modulation of 5-BDBD at Human P2X4 Receptors

Stefan Bidula, Izzuddin Bin Nadzirin, Marco Cominetti, Harry Hickey, Sean A. Cullum, Mark Searcey, Ralf Schmid and Samuel J. Fountain
Molecular Pharmacology January 2022, 101 (1) 33-44; DOI: https://doi.org/10.1124/molpharm.121.000402
Stefan Bidula
School of Biological Sciences (S.B., I.B.N., H.H., S.A.C., S.J.F.), and School of Pharmacy (M.C., M.S.), University of East Anglia, Norwich Research Park, United Kingdom; and Leicester Institute of Structural and Chemical Biology (R.S.), and Department of Molecular and Cell Biology (R.S.), University of Leicester, United Kingdom
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Izzuddin Bin Nadzirin
School of Biological Sciences (S.B., I.B.N., H.H., S.A.C., S.J.F.), and School of Pharmacy (M.C., M.S.), University of East Anglia, Norwich Research Park, United Kingdom; and Leicester Institute of Structural and Chemical Biology (R.S.), and Department of Molecular and Cell Biology (R.S.), University of Leicester, United Kingdom
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Marco Cominetti
School of Biological Sciences (S.B., I.B.N., H.H., S.A.C., S.J.F.), and School of Pharmacy (M.C., M.S.), University of East Anglia, Norwich Research Park, United Kingdom; and Leicester Institute of Structural and Chemical Biology (R.S.), and Department of Molecular and Cell Biology (R.S.), University of Leicester, United Kingdom
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Harry Hickey
School of Biological Sciences (S.B., I.B.N., H.H., S.A.C., S.J.F.), and School of Pharmacy (M.C., M.S.), University of East Anglia, Norwich Research Park, United Kingdom; and Leicester Institute of Structural and Chemical Biology (R.S.), and Department of Molecular and Cell Biology (R.S.), University of Leicester, United Kingdom
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Sean A. Cullum
School of Biological Sciences (S.B., I.B.N., H.H., S.A.C., S.J.F.), and School of Pharmacy (M.C., M.S.), University of East Anglia, Norwich Research Park, United Kingdom; and Leicester Institute of Structural and Chemical Biology (R.S.), and Department of Molecular and Cell Biology (R.S.), University of Leicester, United Kingdom
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Mark Searcey
School of Biological Sciences (S.B., I.B.N., H.H., S.A.C., S.J.F.), and School of Pharmacy (M.C., M.S.), University of East Anglia, Norwich Research Park, United Kingdom; and Leicester Institute of Structural and Chemical Biology (R.S.), and Department of Molecular and Cell Biology (R.S.), University of Leicester, United Kingdom
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Ralf Schmid
School of Biological Sciences (S.B., I.B.N., H.H., S.A.C., S.J.F.), and School of Pharmacy (M.C., M.S.), University of East Anglia, Norwich Research Park, United Kingdom; and Leicester Institute of Structural and Chemical Biology (R.S.), and Department of Molecular and Cell Biology (R.S.), University of Leicester, United Kingdom
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Samuel J. Fountain
School of Biological Sciences (S.B., I.B.N., H.H., S.A.C., S.J.F.), and School of Pharmacy (M.C., M.S.), University of East Anglia, Norwich Research Park, United Kingdom; and Leicester Institute of Structural and Chemical Biology (R.S.), and Department of Molecular and Cell Biology (R.S.), University of Leicester, United Kingdom
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Article Information

vol. 101 no. 1 33-44
DOI 
https://doi.org/10.1124/molpharm.121.000402
PubMed 
34718224

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received August 27, 2021
  • Accepted October 17, 2021
  • Published online December 17, 2021.

Article Versions

  • Earlier version (October 30, 2021 - 03:46).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2021 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Stefan Bidula,
  2. Izzuddin Bin Nadzirin,
  3. Marco Cominetti,
  4. Harry Hickey,
  5. Sean A. Cullum,
  6. Mark Searcey,
  7. Ralf Schmid, and
  8. Samuel J. Fountain
  1. School of Biological Sciences (S.B., I.B.N., H.H., S.A.C., S.J.F.), and School of Pharmacy (M.C., M.S.), University of East Anglia, Norwich Research Park, United Kingdom; and Leicester Institute of Structural and Chemical Biology (R.S.), and Department of Molecular and Cell Biology (R.S.), University of Leicester, United Kingdom
  1. Address correspondence to:
    Professor Samuel Fountain, School of Biological Sciences, University of East Anglia, NR4 7TJ, UK. E-mail: s.j.fountain{at}uea.ac.uk
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Molecular Pharmacology: 101 (1)
Molecular Pharmacology
Vol. 101, Issue 1
1 Jan 2022
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Research ArticleArticle

5-BDBD Antagonist Action through an Allosteric Site on P2X4

Stefan Bidula, Izzuddin Bin Nadzirin, Marco Cominetti, Harry Hickey, Sean A. Cullum, Mark Searcey, Ralf Schmid and Samuel J. Fountain
Molecular Pharmacology January 1, 2022, 101 (1) 33-44; DOI: https://doi.org/10.1124/molpharm.121.000402

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Research ArticleArticle

5-BDBD Antagonist Action through an Allosteric Site on P2X4

Stefan Bidula, Izzuddin Bin Nadzirin, Marco Cominetti, Harry Hickey, Sean A. Cullum, Mark Searcey, Ralf Schmid and Samuel J. Fountain
Molecular Pharmacology January 1, 2022, 101 (1) 33-44; DOI: https://doi.org/10.1124/molpharm.121.000402
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