Research ArticleEmerging Concepts
Extrachromosomal Circular DNAs, Amplified Oncogenes, and CRISPR-Cas9 System
Fatemeh Pourrajab and Mohamad Reza Zare-Khormizi
Molecular Pharmacology October 2022, 102 (4) 209-215; DOI: https://doi.org/10.1124/molpharm.122.000553
Fatemeh Pourrajab
Reproductive Immunology Research Center (F.P.), Nutrition and Food Security Research Center (F.P.), Hematology and Oncology Research Center (F.P.), Biotechnology Research Center, International Campus (F.P.), and School of Medicine (M.R.Z.-K.), Shahid Sadoughi University of Medical Sciences, Yazd, Iran; and Cardiovascular Research Center, Kerman University of Medical Sciences, Kerman, Iran (M.R.Z.-K.)
Mohamad Reza Zare-Khormizi
Reproductive Immunology Research Center (F.P.), Nutrition and Food Security Research Center (F.P.), Hematology and Oncology Research Center (F.P.), Biotechnology Research Center, International Campus (F.P.), and School of Medicine (M.R.Z.-K.), Shahid Sadoughi University of Medical Sciences, Yazd, Iran; and Cardiovascular Research Center, Kerman University of Medical Sciences, Kerman, Iran (M.R.Z.-K.)

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In this issue
Research ArticleEmerging Concepts
Extrachromosomal circular DNAs and CRISPR-Cas9 System
Fatemeh Pourrajab and Mohamad Reza Zare-Khormizi
Molecular Pharmacology October 1, 2022, 102 (4) 209-215; DOI: https://doi.org/10.1124/molpharm.122.000553
Jump to section
- Article
- Abstract
- Introduction
- EccDNA and Copy Number Variations in Somatic Tissues
- Recurrent Oncogenes in Highly Amplified eccDNAs
- EccDNAs in Tumor Metastasis and Patient Outcomes
- CRISPR-Cas9 as a Tool for Gene Targeting
- Gene-Independent Copy Number LOF Effects by CRISPR-Cas9
- Discussion
- Acknowledgments
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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