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Research ArticleEmerging Concepts

The Emerging Structural Pharmacology of ATP-Sensitive Potassium Channels

Jing-Xiang Wu, Dian Ding and Lei Chen
Molecular Pharmacology November 2022, 102 (5) 234-239; DOI: https://doi.org/10.1124/molpharm.122.000570
Jing-Xiang Wu
State Key Laboratory of Membrane Biology, College of Future Technology, Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine (J.-X.W., D.D., L.C.), Peking-Tsinghua Center for Life Sciences (D.D., L.C.), Academy for Advanced Interdisciplinary Studies (D.D., L.C.), and National Biomedical Imaging Center, Peking University, Beijing, China (J.-X.W., D.D., L.C.)
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Dian Ding
State Key Laboratory of Membrane Biology, College of Future Technology, Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine (J.-X.W., D.D., L.C.), Peking-Tsinghua Center for Life Sciences (D.D., L.C.), Academy for Advanced Interdisciplinary Studies (D.D., L.C.), and National Biomedical Imaging Center, Peking University, Beijing, China (J.-X.W., D.D., L.C.)
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Lei Chen
State Key Laboratory of Membrane Biology, College of Future Technology, Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine (J.-X.W., D.D., L.C.), Peking-Tsinghua Center for Life Sciences (D.D., L.C.), Academy for Advanced Interdisciplinary Studies (D.D., L.C.), and National Biomedical Imaging Center, Peking University, Beijing, China (J.-X.W., D.D., L.C.)
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Article Information

vol. 102 no. 5 234-239
DOI 
https://doi.org/10.1124/molpharm.122.000570
PubMed 
36253099

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received May 31, 2022
  • Accepted August 29, 2022
  • Published online October 17, 2022.

Article Versions

  • Earlier version (September 2, 2022 - 02:54).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2022 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jing-Xiang Wu1,
  2. Dian Ding1, and
  3. Lei Chen
  1. State Key Laboratory of Membrane Biology, College of Future Technology, Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine (J.-X.W., D.D., L.C.), Peking-Tsinghua Center for Life Sciences (D.D., L.C.), Academy for Advanced Interdisciplinary Studies (D.D., L.C.), and National Biomedical Imaging Center, Peking University, Beijing, China (J.-X.W., D.D., L.C.)
  1. Address correspondence to:
    Lei Chen, Room 218, Research Building No. 2, Peking University, Yiheyuan Road No.5, Beijing, China 100871. E-mail: chenlei2016{at}pku.edu.cn
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Molecular Pharmacology: 102 (5)
Molecular Pharmacology
Vol. 102, Issue 5
1 Nov 2022
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Research ArticleEmerging Concepts

Cryo-EM Reveals KATP Drug Binding Sites

Jing-Xiang Wu, Dian Ding and Lei Chen
Molecular Pharmacology November 1, 2022, 102 (5) 234-239; DOI: https://doi.org/10.1124/molpharm.122.000570

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Research ArticleEmerging Concepts

Cryo-EM Reveals KATP Drug Binding Sites

Jing-Xiang Wu, Dian Ding and Lei Chen
Molecular Pharmacology November 1, 2022, 102 (5) 234-239; DOI: https://doi.org/10.1124/molpharm.122.000570
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  • Article
    • Abstract
    • The Emerging Concept of ATP-Sensitive Potassium Channel Structural Pharmacology
    • The IS Binding Site of KATP Channel
    • The KCO Binding Site of KATP Channel
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