Coincident Regulation of PLCβ Signaling by Gq-Coupled and μ-Opioid Receptors Opposes Opioid-Mediated Antinociception

Gissell A. Sanchez; Emily M. Jutkiewicz; Susan Ingram; Alan V. Smrcka

doi:10.1124/molpharm.122.000541

Research ArticleArticle

Coincident Regulation of PLCβ Signaling by Gq-Coupled and μ-Opioid Receptors Opposes Opioid-Mediated Antinociception

Gissell A. Sanchez, Emily M. Jutkiewicz, Susan Ingram and Alan V. Smrcka

Molecular Pharmacology December 2022, 102 (6) 269-279; DOI: https://doi.org/10.1124/molpharm.122.000541

Gissell A. Sanchez

Department of Pharmacology, University of Michigan, Ann Arbor, Michigan (G.A.S., E.M.J., A.V.S.) and Department of Neurologic Surgery, Oregon Health Sciences University, Portland, Oregon (S.I.)

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Emily M. Jutkiewicz

Department of Pharmacology, University of Michigan, Ann Arbor, Michigan (G.A.S., E.M.J., A.V.S.) and Department of Neurologic Surgery, Oregon Health Sciences University, Portland, Oregon (S.I.)

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Susan Ingram

Department of Pharmacology, University of Michigan, Ann Arbor, Michigan (G.A.S., E.M.J., A.V.S.) and Department of Neurologic Surgery, Oregon Health Sciences University, Portland, Oregon (S.I.)

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Alan V. Smrcka

Department of Pharmacology, University of Michigan, Ann Arbor, Michigan (G.A.S., E.M.J., A.V.S.) and Department of Neurologic Surgery, Oregon Health Sciences University, Portland, Oregon (S.I.)

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Molecular Pharmacology

Vol. 102, Issue 6

1 Dec 2022

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Research ArticleArticle

Gα_q and βγ Cooperatively Regulate MOR Signaling via PLCβ3

Gissell A. Sanchez, Emily M. Jutkiewicz, Susan Ingram and Alan V. Smrcka

Molecular Pharmacology December 1, 2022, 102 (6) 269-279; DOI: https://doi.org/10.1124/molpharm.122.000541

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Research ArticleArticle

Gα_q and βγ Cooperatively Regulate MOR Signaling via PLCβ3

Gissell A. Sanchez, Emily M. Jutkiewicz, Susan Ingram and Alan V. Smrcka

Molecular Pharmacology December 1, 2022, 102 (6) 269-279; DOI: https://doi.org/10.1124/molpharm.122.000541

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