Functional Assessment of Cancer-Linked Mutations in Sensitive Regions of Regulators of G Protein Signaling Predicted by Three-Dimensional Missense Tolerance Ratio Analysis

Carolina Montañez-Miranda; Riley E. Perszyk; Nicholas H. Harbin; Jennifer Okalova; Suneela Ramineni; Stephen F. Traynelis; John R. Hepler

doi:10.1124/molpharm.122.000614

Research ArticleArticle

Functional Assessment of Cancer-Linked Mutations in Sensitive Regions of Regulators of G Protein Signaling Predicted by Three-Dimensional Missense Tolerance Ratio Analysis

Carolina Montañez-Miranda, Riley E. Perszyk, Nicholas H. Harbin, Jennifer Okalova, Suneela Ramineni, Stephen F. Traynelis and John R. Hepler

Molecular Pharmacology January 2023, 103 (1) 21-37; DOI: https://doi.org/10.1124/molpharm.122.000614

Carolina Montañez-Miranda

Department of Pharmacology and Chemical Biology (C.M.-M., R.E.P., N.H.H., S.R., S.F.T., J.R.H.) and Aflac Cancer and Blood Disorders Center, Department of Pediatrics (J.O.), Emory University School of Medicine, Atlanta, Georgia

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Riley E. Perszyk

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Nicholas H. Harbin

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Jennifer Okalova

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Suneela Ramineni

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Stephen F. Traynelis

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John R. Hepler

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vol. 103 no. 1 21-37

DOI

https://doi.org/10.1124/molpharm.122.000614

PubMed

36384958

Published By

American Society for Pharmacology and Experimental Therapeutics

Print ISSN

0026-895X

Online ISSN

1521-0111

History

Received August 16, 2022
Accepted October 18, 2022
Published online December 28, 2022.

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Earlier version (November 16, 2022 - 13:10).
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Author Information

Carolina Montañez-Miranda,
Riley E. Perszyk,
Nicholas H. Harbin,
Jennifer Okalova,
Suneela Ramineni,
Stephen F. Traynelis, and
John R. Hepler

Department of Pharmacology and Chemical Biology (C.M.-M., R.E.P., N.H.H., S.R., S.F.T., J.R.H.) and Aflac Cancer and Blood Disorders Center, Department of Pediatrics (J.O.), Emory University School of Medicine, Atlanta, Georgia

Address correspondence to:
Dr. John R. Hepler, Department of Pharmacology and Chemical Biology, Emory University School of Medicine, G205 O. Wayne Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30320-3090. E-mail: Jhepler{at}emory.edu

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Research ArticleArticle

3DMTR and Functional Analysis of Mutations in RGS Proteins

Carolina Montañez-Miranda, Riley E. Perszyk, Nicholas H. Harbin, Jennifer Okalova, Suneela Ramineni, Stephen F. Traynelis and John R. Hepler

Molecular Pharmacology January 1, 2023, 103 (1) 21-37; DOI: https://doi.org/10.1124/molpharm.122.000614

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Research ArticleArticle

3DMTR and Functional Analysis of Mutations in RGS Proteins

Carolina Montañez-Miranda, Riley E. Perszyk, Nicholas H. Harbin, Jennifer Okalova, Suneela Ramineni, Stephen F. Traynelis and John R. Hepler

Molecular Pharmacology January 1, 2023, 103 (1) 21-37; DOI: https://doi.org/10.1124/molpharm.122.000614

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Functional Assessment of Cancer-Linked Mutations in Sensitive Regions of Regulators of G Protein Signaling Predicted by Three-Dimensional Missense Tolerance Ratio Analysis

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