Functional Assessment of Cancer-Linked Mutations in Sensitive Regions of Regulators of G Protein Signaling Predicted by Three-Dimensional Missense Tolerance Ratio Analysis

Carolina Montañez-Miranda; Riley E. Perszyk; Nicholas H. Harbin; Jennifer Okalova; Suneela Ramineni; Stephen F. Traynelis; John R. Hepler

doi:10.1124/molpharm.122.000614

Research ArticleArticle

Functional Assessment of Cancer-Linked Mutations in Sensitive Regions of Regulators of G Protein Signaling Predicted by Three-Dimensional Missense Tolerance Ratio Analysis

Carolina Montañez-Miranda, Riley E. Perszyk, Nicholas H. Harbin, Jennifer Okalova, Suneela Ramineni, Stephen F. Traynelis and John R. Hepler

Molecular Pharmacology January 2023, 103 (1) 21-37; DOI: https://doi.org/10.1124/molpharm.122.000614

Carolina Montañez-Miranda

Department of Pharmacology and Chemical Biology (C.M.-M., R.E.P., N.H.H., S.R., S.F.T., J.R.H.) and Aflac Cancer and Blood Disorders Center, Department of Pediatrics (J.O.), Emory University School of Medicine, Atlanta, Georgia

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Riley E. Perszyk

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Nicholas H. Harbin

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Jennifer Okalova

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Suneela Ramineni

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Stephen F. Traynelis

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John R. Hepler

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Molecular Pharmacology

Vol. 103, Issue 1

1 Jan 2023

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