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Molecular Pharmacology

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Table of Contents

February 01, 2023; Volume 103,Issue 2

Articles

  • Open Access
    Multiplex G Protein–Coupled Receptor Screen Reveals Reliably Acting Agonists and a Gq-Phospholipase C Coupling Mode of GPR30/GPER1
    Nicole Urban, Marion Leonhardt and Michael Schaefer
    Molecular Pharmacology February 2023, 103 (2) 48-62; DOI: https://doi.org/10.1124/molpharm.122.000580
  • You have access
    Insights Into the Differential Desensitization of α4β2 Nicotinic Acetylcholine Receptor Isoforms Obtained With Positive Allosteric Modulation of Mutant Receptors
    Roger L. Papke and Clare Stokes
    Molecular Pharmacology February 2023, 103 (2) 63-76; DOI: https://doi.org/10.1124/molpharm.122.000591
  • Open Access
    Differences in Sustained Cellular Effects of MET inhibitors Are Driven by Prolonged Target Engagement and Lysosomal Retention
    Nina Berges, Jan Henrik Klug, Anna Eicher, Jennifer Loehr, Daniel Schwarz, Joerg Bomke, Birgitta Leuthner, Dominique Perrin and Oliver Schadt
    Molecular Pharmacology February 2023, 103 (2) 77-88; DOI: https://doi.org/10.1124/molpharm.122.000590
  • The Isoleucine at Position 118 in Transmembrane 2 Is Responsible for the Selectivity of Xamoterol, Nebivolol, and ICI89406 for the Human <em>β</em>1-Adrenoceptor
    Open Access
    The Isoleucine at Position 118 in Transmembrane 2 Is Responsible for the Selectivity of Xamoterol, Nebivolol, and ICI89406 for the Human β1-Adrenoceptor
    Victor Jun Yu Lim, Richard G. W. Proudman, Stefania Monteleone, Peter Kolb and Jillian G. Baker
    Molecular Pharmacology February 2023, 103 (2) 89-99; DOI: https://doi.org/10.1124/molpharm.122.000583
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    A Complete Endocannabinoid Signaling System Modulates Synaptic Transmission between Human Induced Pluripotent Stem Cell–Derived Neurons
    Melissa J. Asher, Hannah M. McMullan, Ao Dong, Yulong Li and Stanley A. Thayer
    Molecular Pharmacology February 2023, 103 (2) 100-112; DOI: https://doi.org/10.1124/molpharm.122.000555

Editorial

  • You have access
    New Leadership and Ideas for Molecular Pharmacology
    Molecular Pharmacology February 2023, 103 (2) 45-47; DOI: https://doi.org/10.1124/molpharm.122.000660
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In this issue

Molecular Pharmacology: 103 (2)
Molecular Pharmacology
Vol. 103, Issue 2
1 Feb 2023
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  • SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7
  • The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints
  • Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases
  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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