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Research ArticleArticle
Open Access

Differences in Sustained Cellular Effects of MET inhibitors Are Driven by Prolonged Target Engagement and Lysosomal Retention

Nina Berges, Jan Henrik Klug, Anna Eicher, Jennifer Loehr, Daniel Schwarz, Joerg Bomke, Birgitta Leuthner, Dominique Perrin and Oliver Schadt
Molecular Pharmacology February 2023, 103 (2) 77-88; DOI: https://doi.org/10.1124/molpharm.122.000590
Nina Berges
The Healthcare Business of Merck KGaA, Darmstadt, Germany
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Jan Henrik Klug
The Healthcare Business of Merck KGaA, Darmstadt, Germany
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Anna Eicher
The Healthcare Business of Merck KGaA, Darmstadt, Germany
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Jennifer Loehr
The Healthcare Business of Merck KGaA, Darmstadt, Germany
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Daniel Schwarz
The Healthcare Business of Merck KGaA, Darmstadt, Germany
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Joerg Bomke
The Healthcare Business of Merck KGaA, Darmstadt, Germany
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Birgitta Leuthner
The Healthcare Business of Merck KGaA, Darmstadt, Germany
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Dominique Perrin
The Healthcare Business of Merck KGaA, Darmstadt, Germany
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Oliver Schadt
The Healthcare Business of Merck KGaA, Darmstadt, Germany
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Article Information

vol. 103 no. 2 77-88
DOI 
https://doi.org/10.1124/molpharm.122.000590
PubMed 
36400432

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received July 13, 2022
  • Accepted October 24, 2022
  • Published online January 19, 2023.

Article Versions

  • Earlier version (November 18, 2022 - 13:20).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2023 The Author(s) This is an open access article distributed under the CC BY Attribution 4.0 International license.

Author Information

  1. Nina Berges,
  2. Jan Henrik Klug,
  3. Anna Eicher,
  4. Jennifer Loehr,
  5. Daniel Schwarz,
  6. Joerg Bomke,
  7. Birgitta Leuthner,
  8. Dominique Perrin, and
  9. Oliver Schadt
  1. The Healthcare Business of Merck KGaA, Darmstadt, Germany
  1. Address correspondence to:
    Nina Berges, the Healthcare Business of Merck KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany. E-mail: nina.berges{at}emdgroup.com
  1. All authors are employees of the healthcare business of Merck KGaA, Darmstadt, Germany, except J.H.K., A.E. and J.L., who were employees at the time this work was conducted. J.H.K.’s contributions formed part of his Master’s thesis.

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Molecular Pharmacology: 103 (2)
Molecular Pharmacology
Vol. 103, Issue 2
1 Feb 2023
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Research ArticleArticle

MET Inhibitors—Mechanisms of Prolonged Target Engagement

Nina Berges, Jan Henrik Klug, Anna Eicher, Jennifer Loehr, Daniel Schwarz, Joerg Bomke, Birgitta Leuthner, Dominique Perrin and Oliver Schadt
Molecular Pharmacology February 1, 2023, 103 (2) 77-88; DOI: https://doi.org/10.1124/molpharm.122.000590

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Research ArticleArticle

MET Inhibitors—Mechanisms of Prolonged Target Engagement

Nina Berges, Jan Henrik Klug, Anna Eicher, Jennifer Loehr, Daniel Schwarz, Joerg Bomke, Birgitta Leuthner, Dominique Perrin and Oliver Schadt
Molecular Pharmacology February 1, 2023, 103 (2) 77-88; DOI: https://doi.org/10.1124/molpharm.122.000590
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