Article Figures & Data
Figures
Tables
Data Supplement
- Supplemental Data -
Table S1. Agonist actions of (-)-Nicotine and levamisole for the Caenorhabditis elegans N-type and L-type nAChRs expressed in Xenopus laevis oocytesa
Figure S1. HPLC of paraherquamide A.
Figure S2. 1H-NMR spectrum of paraherquamide A purified from the fermentation products of of Penicillium sp. OK188 strain in the okara medium.
Figure S3. 13C-NMR spectrum of paraherquamide A purified from the fermentation products of of Penicillium sp. OK188 strain in the okara medium.
Figure S4. Antagonist actions of derquantel on C. elegans N-type and L-type nAChRs expressed in X. laevis oocytes.
Figure S5. Electron density maps for Ls-AChBP with paraherquamide A bound.
Figure S6. Hydrogen bond formation of the hydroxy group of paraherquamide A with the backbone of Trp143 and the hydroxy group of Tyr192.
Figure S7. Concentration-agonist action relationship of (-)-nicotine on wild type C. elegans N-type (ACR-16) nAChR expressed in X. laevis oocytes
Figure S8. Effects of mutations in loop F on the agonist actions of (-)-nicotine and levamisole on the C. elegans N-type and L-type nAChRs expressed in X. laevis oocytes.
Figure S9. Superposition of Ls-AChBP-derquantel complex model to the X-ray crystal structure of Ls-AChBP-paraherquamide A complex.
Caption for PDB (7DJI.pdb).
- Supplemental Data -
Protein Data Bank 7DJI
- Supplemental Data -