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Molecular Pharmacology

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Research ArticleArticle

Rigorous Characterization of Allosteric Modulation of the Human Metabotropic Glutamate Receptor 1 Reveals Probe- and Assay-Dependent Pharmacology

Ashwin Muraleetharan, Yuyang Wang, Matthew C. Rowe, Ashleigh Gould, Karen J. Gregory and Shane D. Hellyer
Molecular Pharmacology June 2023, 103 (6) 325-338; DOI: https://doi.org/10.1124/molpharm.122.000664
Ashwin Muraleetharan
Drug Discovery Biology (A.M., Y.W., M.C.R., A.G., K.J.G., S.D.H.) and ARC Centre for Cryo-Electron Microscopy of Membrane Proteins (K.J.G.), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
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Yuyang Wang
Drug Discovery Biology (A.M., Y.W., M.C.R., A.G., K.J.G., S.D.H.) and ARC Centre for Cryo-Electron Microscopy of Membrane Proteins (K.J.G.), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
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Matthew C. Rowe
Drug Discovery Biology (A.M., Y.W., M.C.R., A.G., K.J.G., S.D.H.) and ARC Centre for Cryo-Electron Microscopy of Membrane Proteins (K.J.G.), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
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Ashleigh Gould
Drug Discovery Biology (A.M., Y.W., M.C.R., A.G., K.J.G., S.D.H.) and ARC Centre for Cryo-Electron Microscopy of Membrane Proteins (K.J.G.), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
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Karen J. Gregory
Drug Discovery Biology (A.M., Y.W., M.C.R., A.G., K.J.G., S.D.H.) and ARC Centre for Cryo-Electron Microscopy of Membrane Proteins (K.J.G.), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
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Shane D. Hellyer
Drug Discovery Biology (A.M., Y.W., M.C.R., A.G., K.J.G., S.D.H.) and ARC Centre for Cryo-Electron Microscopy of Membrane Proteins (K.J.G.), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
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Article Information

vol. 103 no. 6 325-338
DOI 
https://doi.org/10.1124/molpharm.122.000664
PubMed 
36921922

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received December 15, 2022
  • Accepted February 21, 2023
  • Published online May 9, 2023.

Article Versions

  • Earlier version (March 15, 2023 - 05:44).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2023 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Ashwin Muraleetharan,
  2. Yuyang Wang,
  3. Matthew C. Rowe,
  4. Ashleigh Gould,
  5. Karen J. Gregory, and
  6. Shane D. Hellyer
  1. Drug Discovery Biology (A.M., Y.W., M.C.R., A.G., K.J.G., S.D.H.) and ARC Centre for Cryo-Electron Microscopy of Membrane Proteins (K.J.G.), Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
  1. Address correspondence to:
    Dr. Shane D. Hellyer, Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, 381 Royal Parade, Parkville VIC 3052, Australia. E-mail: shane.hellyer{at}monash.edu
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Apr 2023114048
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Molecular Pharmacology: 103 (6)
Molecular Pharmacology
Vol. 103, Issue 6
1 Jun 2023
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Research ArticleArticle

Allosteric Modulation of Metabotropic Glutamate Receptor 1

Ashwin Muraleetharan, Yuyang Wang, Matthew C. Rowe, Ashleigh Gould, Karen J. Gregory and Shane D. Hellyer
Molecular Pharmacology June 1, 2023, 103 (6) 325-338; DOI: https://doi.org/10.1124/molpharm.122.000664

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Research ArticleArticle

Allosteric Modulation of Metabotropic Glutamate Receptor 1

Ashwin Muraleetharan, Yuyang Wang, Matthew C. Rowe, Ashleigh Gould, Karen J. Gregory and Shane D. Hellyer
Molecular Pharmacology June 1, 2023, 103 (6) 325-338; DOI: https://doi.org/10.1124/molpharm.122.000664
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