Abstract
Chlorpromazine binds reversibly to brain tubulin via two well-resolved processes. One chlorpromazine molecule binds strongly compared with 8-9 molecules that bind weakly. Binding to the higher-affinity site is chiefly entropy-driven, implicating hydrophobic forces. The two binding processes are compared with the biological activities of chlorpromazine in vitro.
ACKNOWLEDGMENT The authors thank Mr. Robert O. Coombs for technical assistance.
- Copyright © 1976 by Academic Press, Inc.
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