Research ArticleArticle
Metabolism of trans-9,10-Dihydroxy-9,10-dihydrobenzo[a]pyrene Occurs Primarily by Arylhydroxylation Rather than Formation of a Diol Epoxide
D. R. THAKKER, H. YAGI, R. E. LEHR, W. LEVIN, M. BUENING, A. Y. H. LU, R. L. CHANG, A. W. WOOD, A. H. CONNEY and D. M. JERINA
Molecular Pharmacology May 1978, 14 (3) 502-513;
D. R. THAKKER
Section on Oxidation Mechanisms, Laboratory of Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014, and Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche, Inc., Nutley, New Jersey 07110
H. YAGI
Section on Oxidation Mechanisms, Laboratory of Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014, and Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche, Inc., Nutley, New Jersey 07110
R. E. LEHR
Section on Oxidation Mechanisms, Laboratory of Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014, and Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche, Inc., Nutley, New Jersey 07110
W. LEVIN
Section on Oxidation Mechanisms, Laboratory of Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014, and Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche, Inc., Nutley, New Jersey 07110
M. BUENING
Section on Oxidation Mechanisms, Laboratory of Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014, and Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche, Inc., Nutley, New Jersey 07110
A. Y. H. LU
Section on Oxidation Mechanisms, Laboratory of Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014, and Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche, Inc., Nutley, New Jersey 07110
R. L. CHANG
Section on Oxidation Mechanisms, Laboratory of Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014, and Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche, Inc., Nutley, New Jersey 07110
A. W. WOOD
Section on Oxidation Mechanisms, Laboratory of Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014, and Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche, Inc., Nutley, New Jersey 07110
A. H. CONNEY
Section on Oxidation Mechanisms, Laboratory of Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014, and Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche, Inc., Nutley, New Jersey 07110
D. M. JERINA
Section on Oxidation Mechanisms, Laboratory of Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014, and Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche, Inc., Nutley, New Jersey 07110
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In this issue
Molecular Pharmacology
Vol. 14, Issue 3
1 May 1978
Research ArticleArticle
Metabolism of trans-9,10-Dihydroxy-9,10-dihydrobenzo[a]pyrene Occurs Primarily by Arylhydroxylation Rather than Formation of a Diol Epoxide
D. R. THAKKER, H. YAGI, R. E. LEHR, W. LEVIN, M. BUENING, A. Y. H. LU, R. L. CHANG, A. W. WOOD, A. H. CONNEY and D. M. JERINA
Molecular Pharmacology May 1, 1978, 14 (3) 502-513;
Research ArticleArticle
Metabolism of trans-9,10-Dihydroxy-9,10-dihydrobenzo[a]pyrene Occurs Primarily by Arylhydroxylation Rather than Formation of a Diol Epoxide
D. R. THAKKER, H. YAGI, R. E. LEHR, W. LEVIN, M. BUENING, A. Y. H. LU, R. L. CHANG, A. W. WOOD, A. H. CONNEY and D. M. JERINA
Molecular Pharmacology May 1, 1978, 14 (3) 502-513;
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