Abstract
The benzodiazepine drugs, diazepam and chlordiazepoxide, have a dual effect on sugar and ion transport in intact rat hemidiaphragms in vitro. At low concentrations they depress 3-methylglucose transport and 45Ca++ influx and increase Na+ and K+ gradients. At higher concentrations all these effects are reversed. It is suggested that the changes in sugar transport are a consequence of alterations in Ca++ fluxes and distribution caused directly or indirectly by these drugs.
ACKNOWLEDGMENTS We thank Mrs. B. Cook for excellent technical assistance.
- Copyright © 1978 by Academic Press, Inc.
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