Abstract
Cordycepin and xylosyladenine were tested for their inhibitory effect upon the phosphorylation of nuclear proteins in L1210 cells in vitro. As indicated by isoelectric focusing of urea-soluble nuclear proteins, the phosphorylation of acidic nonhistone chromosomal proteins was strongly inhibited by both nucleosides, particularly in the presence of the adenosine deaminase inhibitor, 2'-deoxycoformycin. These observations may explain, in part, the inhibitory effect of both drugs upon transcription.
- Copyright © 1978 by Academic Press, Inc.
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Inhibition of the Phosphorylation of Nonhistone Chromosomal Proteins by Cordycepin and Xylosyladenine in L1210 Cells in Vitro
