Abstract
Significant amounts of cytochrome P-450 have been detected spectrally in purified nucleoli obtained from the livers of 3-methylcholanthrene-treated rats. Using monospecific antibody to microsomal cytochrome P-450c (P-448), we have shown that the nucleolar and microsomal enzymes are immunochemically identical. These nucleoli also contained epoxide hydrolase and NADPH-cytochrome c reductase activities, both of which were immunochemically identical to their respective microsomal counterparts.
- Copyright © 1980 by The American Society for Pharmacology and Experimental Therapeutics
MolPharm articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.