Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Molecular Pharmacology
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Molecular Pharmacology

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit molpharm on Facebook
  • Follow molpharm on Twitter
  • Follow molpharm on LinkedIn
Research ArticleArticle

Differential Induction by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin of Multiple Forms of Rabbit Microsomal Cytochrome P-450: Evidence for Tissue Specificity

HENG H. LIEM, URSULA MULLER-EBERHARD and ERIC F. JOHNSON
Molecular Pharmacology November 1980, 18 (3) 565-570;
HENG H. LIEM
Department of Biochemistsy, Scripps Clinic and Research Foundation, La Jolla, California 92037
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
URSULA MULLER-EBERHARD
Department of Biochemistsy, Scripps Clinic and Research Foundation, La Jolla, California 92037
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
ERIC F. JOHNSON
Department of Biochemistsy, Scripps Clinic and Research Foundation, La Jolla, California 92037
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

Four forms of cytochrome P-450, forms 2, 3, 4, and 6, are presently being isolated and characterized in this laboratory. Induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin of specific forms of microsomal cytochrome P-450 was studied in adult rabbit kidney and lung. The induction of a single prominent cytochrome P-450 form was observed; this cytochrome was identified as form 6. The assigmnent of the inducible pulmonary and renal cytochrome as form 6 was established by its mobility on sodium dodecyl sulfate-polyacrylamide gel electrophoresis, its peptide map, and its specific antigenicity. In contrast, previous findings have shown that form 4 is the major cytochrome P-450 induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in adult rabbit liver. Thus, the specific induction of cytochrome P-450 forms 4 and 6 is tissue dependent.

ACKNOWLEDGMENTS The technical assistance of Maria Balga, Maryann Zounes, and Kendis Cox is gratefully acknowledged. We wish to thank Diane Montoya and Pat Matson for preparation of the manuscript.

  • Copyright © 1980 by The American Society for Pharmacology and Experimental Therapeutics

MolPharm articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Molecular Pharmacology
Vol. 18, Issue 3
1 Nov 1980
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Molecular Pharmacology article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Differential Induction by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin of Multiple Forms of Rabbit Microsomal Cytochrome P-450: Evidence for Tissue Specificity
(Your Name) has forwarded a page to you from Molecular Pharmacology
(Your Name) thought you would be interested in this article in Molecular Pharmacology.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

Differential Induction by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin of Multiple Forms of Rabbit Microsomal Cytochrome P-450: Evidence for Tissue Specificity

HENG H. LIEM, URSULA MULLER-EBERHARD and ERIC F. JOHNSON
Molecular Pharmacology November 1, 1980, 18 (3) 565-570;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

Differential Induction by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin of Multiple Forms of Rabbit Microsomal Cytochrome P-450: Evidence for Tissue Specificity

HENG H. LIEM, URSULA MULLER-EBERHARD and ERIC F. JOHNSON
Molecular Pharmacology November 1, 1980, 18 (3) 565-570;
Reddit logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Pharmacological characterization of the human α6β4 nAChR
  • Mechanism of the selective action of paraherquamide A
  • Fatty Acid Amide Hydrolase in Cisplatin Nephrotoxicity
Show more Article

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About Molecular Pharmacology
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Journal of Pharmacology and Experimental Therapeutics
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0111 (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics