Abstract
Several flavoenzymes are compared for their ability to catalyze reductive glycosidic cleavage of anthracycline antibiotics and to promote oxygen consumption in the presence of the antibiotics. NADPH cytochrome P-450 reductase, xanthine oxidase, nitrate reductase, NADH cytochrome c reductase, and lipoamide dehydrogenase catalyzed with decreasing specific activity the reductive glycosidic cleavage of daunorubicin and showed enhanced oxygen consumption in the presence of daunorubicin. Gluthione reductases, L-amino acid oxidase, D-amino acid oxidase, D-glucose oxidase, and lactic dehydrogenase were inactive. All of those flavoenzymes which catalyze reductive glycosidic cleavage possess single-electron transfer systems.
ACKNOWLEDGMENT We wish to thank Ms. Helen Chlewicki in the preparation of the manuscript.
- Copyright © 1981 by The American Society for Pharmacology and Experimental Therapeutics
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