Abstract
The addition to liver microsomes of various substrates, such as hexobarbital, aminopyrine, or aniline, causes two types of spectral changes. Spectrophotometric studies suggest that these changes are related to substrate interaction with a microsomal hemoprotein. On the basis of these observations, two hypotheses are suggested to explain the interaction of substrates with the liver microsomal mixed function oxidase system.
This work was supported in part by a grant from the National Science Foundation (GB 2451) and grants (AM 07217, AM 04484, and GM 12202) of the U. S. Public Health Service. The studies were carried out during tenures of U.S.P.H.S. Research Career Development Awards HE 25132 to D. Y. Cooper and GM-K3-4111 to R. W. Estabrook.
- Copyright ©, 1966, by Academic Press Inc.
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Drug Interaction with Hepatic Microsomal Cytochrome
