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Molecular Pharmacology

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Research ArticleArticle

Evaluation of the Biochemical Effects Produced in Vivo by Inhibitors of the Three Enzymes Involved in Norepinephrine Biosynthesis

SIDNEY UDENFRIEND, PEROLA ZALTZMAN-NIRENBERG, ROBERT GORDON and SYDNEY SPECTOR
Molecular Pharmacology April 1966, 2 (2) 95-105;
SIDNEY UDENFRIEND
Laboratory of Clinical Biochemistry and the Experimental Therapeutics Branch, National Heart Institute, National Institutes of Health, Bethesda, Maryland, and Department of Pharmacology, George Washington University, Washington, D. C.
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PEROLA ZALTZMAN-NIRENBERG
Laboratory of Clinical Biochemistry and the Experimental Therapeutics Branch, National Heart Institute, National Institutes of Health, Bethesda, Maryland, and Department of Pharmacology, George Washington University, Washington, D. C.
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ROBERT GORDON
Laboratory of Clinical Biochemistry and the Experimental Therapeutics Branch, National Heart Institute, National Institutes of Health, Bethesda, Maryland, and Department of Pharmacology, George Washington University, Washington, D. C.
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SYDNEY SPECTOR
Laboratory of Clinical Biochemistry and the Experimental Therapeutics Branch, National Heart Institute, National Institutes of Health, Bethesda, Maryland, and Department of Pharmacology, George Washington University, Washington, D. C.
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Abstract

Inhibitors of tyrosine hydroxylase, dopa decarboxylase, and dopamine-β-oxidase have been compared with respect to the in vivo conversion of tyrosine-14C and dopa-3H to norepinephrine. Tyrosine hydroxylase inhibitors were found to be the most effective in blocking formation of norepinephrine from tyrosine-14C. The lowering of norepinephrine levels in guinea pig tissues by α-methyltyrosine was found to be directly related to the degree of inhibition of tyrosine hydroxylase. Furthermore, with α-methyltyrosine, the measured inhibition of norepinephrine synthesis from tyrosine was found to be exactly the same as the calculated inhibition of tyrosine hydroxylase. This could be true only if tyrosine hydroxylase were the rate-limiting step in the overall biosynthesis of norepinephrine.

ACKNOWLEDGMENT The work of R. G. was supported by a Public Health Service Training Grant 51, GM26 from the Division of General Medical Sciences, Public Health Service, Bethesda, Maryland, and is in partial fulfillment of the requirements for the Ph.D. in Pharmacology at George Washington University.

  • Copyright ©, 1966, by Academic Press Inc.

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Molecular Pharmacology
Vol. 2, Issue 2
1 Apr 1966
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Research ArticleArticle

Evaluation of the Biochemical Effects Produced in Vivo by Inhibitors of the Three Enzymes Involved in Norepinephrine Biosynthesis

SIDNEY UDENFRIEND, PEROLA ZALTZMAN-NIRENBERG, ROBERT GORDON and SYDNEY SPECTOR
Molecular Pharmacology April 1, 1966, 2 (2) 95-105;

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Research ArticleArticle

Evaluation of the Biochemical Effects Produced in Vivo by Inhibitors of the Three Enzymes Involved in Norepinephrine Biosynthesis

SIDNEY UDENFRIEND, PEROLA ZALTZMAN-NIRENBERG, ROBERT GORDON and SYDNEY SPECTOR
Molecular Pharmacology April 1, 1966, 2 (2) 95-105;
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