Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Molecular Pharmacology
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Molecular Pharmacology

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit molpharm on Facebook
  • Follow molpharm on Twitter
  • Follow molpharm on LinkedIn
Research ArticleArticle

Effect of Drugs on the Lipolytic Action of Hormones in Isolated Fat Cells

JOHN N. FAIN, DAVID J. GALTON and VANCO P. KOVACEV
Molecular Pharmacology June 1966, 2 (3) 237-247;
JOHN N. FAIN
National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland, and Division of Biological and Medical Sciences, Brown University, Providence, Rhode Island
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DAVID J. GALTON
National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland, and Division of Biological and Medical Sciences, Brown University, Providence, Rhode Island
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
VANCO P. KOVACEV
National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland, and Division of Biological and Medical Sciences, Brown University, Providence, Rhode Island
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

The effect of various drugs on the lipolytic action of growth hormone plus dexamethasone was compared with that on the action of ACTH and epinephrine in isolated fat cells from starved rats. Phenoxybenzamine reduced the acceleration of lipolysis by growth hormone plus dexamethasone but had no significant effect on that of either ACTH or epinephrine. Butoxamine inhibited the effect of growth hormone plus dexamethasone and of ACTH on lipolysis.

dl-β-hydroxy-N-tert-butyl-2,4-dichlorophenethylamine (DCB) stimulated lipolysis and did not prevent the acceleration of lipolysis by growth hormone and dexamethasone. There was no lipolytic effect of epinephrine and ACTH in the presence of DCB. Propranolol, which is a beta adrenergic blocking agent with little sympathomimetic activity, completely blocked the lipolytic effect of epinephrine. Propranolol did not inhibit the lipolytic action of either ACTH or growth hormone plus dexamethasone.

Nicotinic acid blocked the lipolytic effect of growth hormone plus dexamethasone, and theophylline potentiated their lipolytic action. Actinomycin D blocked the lipolytic effect of growth hormone and dexamethasone, but not of epinephrine.

ACKNOWLEDGMENTS The authors would like to thank Professor R. E. Parks, Jr., for his comments (during the preparation of this manuscript and Miss Nancy Davis for her technical assistance in some of the experiments.

  • Copyright ©, 1966, by Academic Press Inc.

MolPharm articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Molecular Pharmacology
Vol. 2, Issue 3
1 Jun 1966
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Editorial Board (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Molecular Pharmacology article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Effect of Drugs on the Lipolytic Action of Hormones in Isolated Fat Cells
(Your Name) has forwarded a page to you from Molecular Pharmacology
(Your Name) thought you would be interested in this article in Molecular Pharmacology.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

Effect of Drugs on the Lipolytic Action of Hormones in Isolated Fat Cells

JOHN N. FAIN, DAVID J. GALTON and VANCO P. KOVACEV
Molecular Pharmacology June 1, 1966, 2 (3) 237-247;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

Effect of Drugs on the Lipolytic Action of Hormones in Isolated Fat Cells

JOHN N. FAIN, DAVID J. GALTON and VANCO P. KOVACEV
Molecular Pharmacology June 1, 1966, 2 (3) 237-247;
Reddit logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Mechanism of the selective action of paraherquamide A
  • Fatty Acid Amide Hydrolase in Cisplatin Nephrotoxicity
  • Use-Dependent Relief of A-887826 Inhibition
Show more Articles

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About Molecular Pharmacology
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Journal of Pharmacology and Experimental Therapeutics
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0111 (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics