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Research ArticleArticle

Prevention by Antidepressant Drugs of Reserpine Effect on Pyridine Nucleotide Metabolism

GERTRUDE P. QUINN, PAUL GREENGARD and MARIA B. REID
Molecular Pharmacology July 1966, 2 (4) 347-351;
GERTRUDE P. QUINN
Department of Biochemistry, Geigy Research, Division of Geigy Chemical Corporation, Ardsley, New York 10502
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PAUL GREENGARD
Department of Biochemistry, Geigy Research, Division of Geigy Chemical Corporation, Ardsley, New York 10502
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MARIA B. REID
Department of Biochemistry, Geigy Research, Division of Geigy Chemical Corporation, Ardsley, New York 10502
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Abstract

A variety of structurally unrelated antidepressant drugs, including both monoamine oxidase (MAO)-inhibitors and non-MAO-inhibitors, prevent the effect of reserpine on the nicotinamide-induced increase in NAD. A single injection of imipramine or iproniazid was effective when given at any time up to several days prior to reserpine. In general, compounds other than antidepressants did not prevent the reserpine effect on NAD metabolism. The ability to block the effect of reserpine on NAD metabolism correlated well with the ability to block the sedative effect of reserpine. The antidepressants did not prevent the effect of chlorpromazine on NAD level, in agreement with their lack of effect on the sedative action of chlorpromazine.

  • Copyright ©, 1966, by Academic Press Inc.

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Molecular Pharmacology
Vol. 2, Issue 4
1 Jul 1966
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Research ArticleArticle

Prevention by Antidepressant Drugs of Reserpine Effect on Pyridine Nucleotide Metabolism

GERTRUDE P. QUINN, PAUL GREENGARD and MARIA B. REID
Molecular Pharmacology July 1, 1966, 2 (4) 347-351;

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Research ArticleArticle

Prevention by Antidepressant Drugs of Reserpine Effect on Pyridine Nucleotide Metabolism

GERTRUDE P. QUINN, PAUL GREENGARD and MARIA B. REID
Molecular Pharmacology July 1, 1966, 2 (4) 347-351;
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