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Molecular Pharmacology

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Research ArticleArticle

Factors Influencing the Metabolism and Distribution of Corticosterone-1,2-3H in the Rat

R. P. MAICKEL, M. T. BUSH, W. R. JONDORF, F. P. MILLER and J. R. GILLETTE
Molecular Pharmacology September 1966, 2 (5) 491-495;
R. P. MAICKEL
Laboratory of Chemical Pharmacology, National Heart Institute, Bethesda, Maryland 20014
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M. T. BUSH
Laboratory of Chemical Pharmacology, National Heart Institute, Bethesda, Maryland 20014
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W. R. JONDORF
Laboratory of Chemical Pharmacology, National Heart Institute, Bethesda, Maryland 20014
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F. P. MILLER
Laboratory of Chemical Pharmacology, National Heart Institute, Bethesda, Maryland 20014
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J. R. GILLETTE
Laboratory of Chemical Pharmacology, National Heart Institute, Bethesda, Maryland 20014
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Abstract

The metabolism and distribution of intravenously administered tracer doses of corticosterone-1,2-3H are not affected by elevated plasma levels of endogenous corticosterone due to cold stress. Pretreatment with methylcholanthrene increased the plasma half-life of the labeled steroid, reflecting a decreased rate of metabolic destruction, but had no effect on the apparent volume of distribution. Pretreatment with phenylbutazone caused an increased volume of distribution with no change in the plasma half-life.

  • Copyright ©, 1966, by Academic Press Inc.

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Molecular Pharmacology
Vol. 2, Issue 5
1 Sep 1966
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Research ArticleArticle

Factors Influencing the Metabolism and Distribution of Corticosterone-1,2-3H in the Rat

R. P. MAICKEL, M. T. BUSH, W. R. JONDORF, F. P. MILLER and J. R. GILLETTE
Molecular Pharmacology September 1, 1966, 2 (5) 491-495;

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Research ArticleArticle

Factors Influencing the Metabolism and Distribution of Corticosterone-1,2-3H in the Rat

R. P. MAICKEL, M. T. BUSH, W. R. JONDORF, F. P. MILLER and J. R. GILLETTE
Molecular Pharmacology September 1, 1966, 2 (5) 491-495;
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