Abstract
The role of protein synthesis in ribonucleic acid (RNA) synthesis was studied using the antibiotic cycloheximide to dissociate the synthesis of these macromolecules in L cells growing in suspension culture. The experimental evidence indicated that uninterrupted synthesis of protein was required for normal ribosomal RNA formation and for normal transport of RNA from nucleus to cytoplasm.
ACKNOWLEDGMENTS I wish to thank Dr. A. E. Osterberg, National Cancer Institute, Bethesda, Maryland, for the gift of actinomycin D, and Mrs. R. Tirey for her excellent technical assistance. This investigation was supported by Public Health Service Grant GM 12359-02 from the Division of General Medical Sciences, by Grant GB 3521 from the National Science Foundation, and by the American Lebanese Syrian Associated Charities (ALSAC).
- Copyright ©, 1966, by Academic Press Inc.
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