Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Molecular Pharmacology
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Molecular Pharmacology

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit molpharm on Facebook
  • Follow molpharm on Twitter
  • Follow molpharm on LinkedIn
Research ArticleArticle

Antimalarial Activity of Selected Aromatic Chelators

II. Substituted Quinolines and Quinoline-N-oxides

L. W. SCHEIBEL and A. ADLER
Molecular Pharmacology July 1981, 20 (1) 218-223;
L. W. SCHEIBEL
Laboratory of Parasitology, The Rockefeller University, New York, New York 10021
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A. ADLER
Laboratory of Parasitology, The Rockefeller University, New York, New York 10021
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

The human malaria parasite, Plasmodium falciparum, has been shown in vitro to be sensitive to lipophilic chelators with high metal-binding constants. Growth inhibition of the parasite correlates directly with the ability of the compound to chelate, and favorable activity has been demonstrated among the alkyl thiocarbamates, pyridine-N-oxides and quinolines. The 5-substituted 8-hydroxyquinolines and 2-mercaptoquinoline-N-oxide, which have had some use in medicine and cosmetics, possess these characteristics. They also exhibit active antimalarial effects in vitro at concentrations as low as 5 x 10-8 M, making them more potent than quinine sulfate in the same system. Antimalarial effects are not antagonized by cobalt or potentiated by iron, but toxicity of the 5-substituted oxines to the parasite is increased by increasing oxygen levels in vitro.

ACKNOWLEDGMENTS The authors wish to thank Dr. Ernest Bueding and Dr. John Seed for evaluating the mutagenicity of these compounds and Dr. W. Trager for his continued support. The authors also wish to think Drs. E. Bueding and A. Albert for suggestions made during the preparation of the manuscript, and Dr. D. H. Steinberg, Dr. Pierre Huve, and the Sigma-Tau Company for the generous donation of drugs.

  • Copyright © 1981 by The American Society for Pharmacology and Experimental Therapeutics

MolPharm articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Molecular Pharmacology
Vol. 20, Issue 1
1 Jul 1981
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Molecular Pharmacology article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Antimalarial Activity of Selected Aromatic Chelators
(Your Name) has forwarded a page to you from Molecular Pharmacology
(Your Name) thought you would be interested in this article in Molecular Pharmacology.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

Antimalarial Activity of Selected Aromatic Chelators

L. W. SCHEIBEL and A. ADLER
Molecular Pharmacology July 1, 1981, 20 (1) 218-223;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

Antimalarial Activity of Selected Aromatic Chelators

L. W. SCHEIBEL and A. ADLER
Molecular Pharmacology July 1, 1981, 20 (1) 218-223;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Upacicalcet binds to the amino acid binding site of CaSR
  • Characterization of GRD and LCCH3 from Human Louse
  • Clc-2 Has Minor Role in Intestinal Cl- Secretion
Show more Article

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About Molecular Pharmacology
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Journal of Pharmacology and Experimental Therapeutics
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0111 (Online)

Copyright © 2022 by the American Society for Pharmacology and Experimental Therapeutics