Abstract
Incubation of rabbit heart membranes at 37° with 10-5 M alprenolol significantly increased the number of beta-receptor binding sites but did not change the adenylate cyclase activity. In the presence of guanine nucleotides, the effect of alprenolol incubation on the beta-receptor was enhanced. When the incubation was carried out at 4°, the alprenolol effect was lost.
- Copyright © 1981 by The American Society for Pharmacology and Experimental Therapeutics
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