Abstract
Benzodioxan derivatives active on the alpha-adrenergic receptor are considered. The half-chair equilibrium of the dioxane ring was studied by 1H-NMR spectroscopy for piperoxan X and quiloflex XII. The preferred conformation was also obtained by PCILO calculations for X. The results were evaluated in order to obtain information about the mechanism of the alpha-adrenergic drug-receptor interaction.
- Copyright © 1981 by The American Society for Pharmacology and Experimental Therapeutics
MolPharm articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.
In this issue
Conformational Properties of Benzodioxan Derivatives with Alpha-Adrenergic Blocking Activity
Jump to section
Related Articles
Cited By...
More in this TOC Section
Similar Articles
Advertisement