Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Molecular Pharmacology
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Molecular Pharmacology

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit molpharm on Facebook
  • Follow molpharm on Twitter
  • Follow molpharm on LinkedIn
Research ArticleArticle

Effects of β-Phenethyl Alcohol on Mouse L Cells in Suspension Culture

II. Effects on the Cell Division Cycle

N. BRUCHOVSKY, S. MAK and J. E. TILL
Molecular Pharmacology March 1967, 3 (2) 133-141;
N. BRUCHOVSKY
Department of Medical Biophysics, University of Toronto, and The Ontario Cancer Institute, Toronto, Ontario, and Department of Biology, Queen’s University, Kingston, Ontario
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S. MAK
Department of Medical Biophysics, University of Toronto, and The Ontario Cancer Institute, Toronto, Ontario, and Department of Biology, Queen’s University, Kingston, Ontario
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J. E. TILL
Department of Medical Biophysics, University of Toronto, and The Ontario Cancer Institute, Toronto, Ontario, and Department of Biology, Queen’s University, Kingston, Ontario
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

The cell division cycle of mouse L cells in suspension culture was changed markedly by exposure of the cells to 0.10% β-phenethyl alcohol (PEA). The progress of cells from the G1 phase into the S phase, from the S phase into the G2 phase and from the G2 phase into mitosis was found to he almost completely stopped for at least 40 hr after the addition of PEA.

Cell populations exposed to PEA for 24 hr and then washed free of PEA showed a partial synchronization of cell proliferation. This partial synchronization appeared to be mainly due to a delay in the recovery of G1- and S-phase cells in PEA-treated populations, rather than to an accumulation of cells in any particular phase of the cell cycle.

The results obtained indicate that PEA has at least two separate effects on the cell division cycle of mammalian cells, an inhibition of the initiation of DNA synthesis, and an interference with the onset of cell division. They support the view that PEA is not simply a specific inhibitor of DNA synthesis in mammalian cells.

ACKNOWLEDGMENTS This work was supported in part by grants from the National Cancer Institute of Canada, and the USPHS (Grant CA-06229-04).

  • Copyright ©, 1967, by Academic Press Inc.

MolPharm articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Molecular Pharmacology
Vol. 3, Issue 2
1 Mar 1967
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Editorial Board (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Molecular Pharmacology article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Effects of β-Phenethyl Alcohol on Mouse L Cells in Suspension Culture
(Your Name) has forwarded a page to you from Molecular Pharmacology
(Your Name) thought you would be interested in this article in Molecular Pharmacology.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

Effects of β-Phenethyl Alcohol on Mouse L Cells in Suspension Culture

N. BRUCHOVSKY, S. MAK and J. E. TILL
Molecular Pharmacology March 1, 1967, 3 (2) 133-141;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

Effects of β-Phenethyl Alcohol on Mouse L Cells in Suspension Culture

N. BRUCHOVSKY, S. MAK and J. E. TILL
Molecular Pharmacology March 1, 1967, 3 (2) 133-141;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • The binding site for KCI807 in the androgen receptor
  • Fatty acid amide hydrolase in cisplatin nephrotoxicity
  • eCB Signaling System in hiPSC-Derived Neuronal Cultures
Show more Articles

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About Molecular Pharmacology
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Journal of Pharmacology and Experimental Therapeutics
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0111 (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics