Abstract
Phosphatidylserine chromatographically purified from human hypothalamus shows a high capacity to bind nonionized noradrenaline in vitro. Experimental results from a two-phase model, consisting of an aqueous phase with noradrenaline and a lipophilic organic phase containing the purified lipid, are found to agree with theoretical predictions on the effects of pH and concentration on binding capacity. The results make it possible to suggest a mechanism for the transport of noradrenaline through the membranes of the brain.
- Copyright ©, 1967, by Academic Press Inc.
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The Binding of Noradrenaline to Phosphatidylserine. In Vitro Studies of an Artificial Model System of Biological Origin
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