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Molecular Pharmacology

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Research ArticleArticle

The Mechanism of Action of Hypoglycin on Long-Chain Fatty Acid Oxidation

M. ENTMAN and R. BRESSLER
Molecular Pharmacology July 1967, 3 (4) 333-340;
M. ENTMAN
Departments of Medicine and Physiology and Pharmacology, Duke University Medical Center, Durham, North Carolina 27706
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R. BRESSLER
Departments of Medicine and Physiology and Pharmacology, Duke University Medical Center, Durham, North Carolina 27706
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Abstract

Intravenous administration of hypoglycin (L-α-amino-β-methylenecyclopropanepropionic acid) to mice resulted in hypoglycemia, which was preceded by a decrease in palmitate oxidation by myocardial homogenates from treated animals. The homogenates from treated animals carried out normal rates of glucose and hexanoate oxidation, but demonstrated depressed levels of palmityl-CoA:carnitine acyltransferase activity. The addition of carnitine to the myocardial homogenates restored both the depressed palmitate oxidation and palmityl-CoA:carnitine acyltransferase activity to normal levels. The administration of carnitine to hypoglycin-treated animals prevented the decreases in myocardial palmitate oxidation, palmityl-CoA:carnitine acyltransferase activity, and the hypoglycemia.

ACKNOWLEDGMENT We wish to thank Dr. H. Lebovitz for his help and advice. Supported by U.S.P.H.S. Grants no. HE 7061 and 5TIGM-516.

  • Copyright ©, 1967, by Academic Press Inc.

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Molecular Pharmacology
Vol. 3, Issue 4
1 Jul 1967
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Research ArticleArticle

The Mechanism of Action of Hypoglycin on Long-Chain Fatty Acid Oxidation

M. ENTMAN and R. BRESSLER
Molecular Pharmacology July 1, 1967, 3 (4) 333-340;

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Research ArticleArticle

The Mechanism of Action of Hypoglycin on Long-Chain Fatty Acid Oxidation

M. ENTMAN and R. BRESSLER
Molecular Pharmacology July 1, 1967, 3 (4) 333-340;
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