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Molecular Pharmacology

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Research ArticleArticle

The Mode of Action of Levallorphan as an Inhibitor of Cell Growth

RICHARD GREENE and BORIS MAGASANIK
Molecular Pharmacology September 1967, 3 (5) 453-472;
RICHARD GREENE
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139
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BORIS MAGASANIK
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139
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Abstract

Levallorphan inhibits the synthesis of RNA, DNA, and protein by Escherichia coli. The drug was found to cause an immediate, dramatic decrease in the amount of intracellular ATP. Evidence is presented which suggests that the decrease in ATP concentration is a consequence of the stimulation of an ATPase. Similar results were obtained in HeLa cells treated with levallorphan.

ACKNOWLEDGMENT This work was supported by Research Grants CY-5210 and GM-7446 from the U.S. Public Health Service. During the course of this work Richard Green was the recipient of a Postdoctoral Fellowship 1 F2 AM-19,349 of the U.S. Public Health Service.

  • Copyright ©, 1967, by Academic Press Inc.

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Molecular Pharmacology
Vol. 3, Issue 5
1 Sep 1967
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Research ArticleArticle

The Mode of Action of Levallorphan as an Inhibitor of Cell Growth

RICHARD GREENE and BORIS MAGASANIK
Molecular Pharmacology September 1, 1967, 3 (5) 453-472;

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Research ArticleArticle

The Mode of Action of Levallorphan as an Inhibitor of Cell Growth

RICHARD GREENE and BORIS MAGASANIK
Molecular Pharmacology September 1, 1967, 3 (5) 453-472;
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