Abstract
Levallorphan inhibits the synthesis of RNA, DNA, and protein by Escherichia coli. The drug was found to cause an immediate, dramatic decrease in the amount of intracellular ATP. Evidence is presented which suggests that the decrease in ATP concentration is a consequence of the stimulation of an ATPase. Similar results were obtained in HeLa cells treated with levallorphan.
ACKNOWLEDGMENT This work was supported by Research Grants CY-5210 and GM-7446 from the U.S. Public Health Service. During the course of this work Richard Green was the recipient of a Postdoctoral Fellowship 1 F2 AM-19,349 of the U.S. Public Health Service.
- Copyright ©, 1967, by Academic Press Inc.
MolPharm articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.
In this issue
The Mode of Action of Levallorphan as an Inhibitor of Cell Growth
Jump to section
Related Articles
Cited By...
More in this TOC Section
Similar Articles
Advertisement