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Research ArticleArticle

Inhibition of Tryptophan Pyrrolase Induction by Carbon Tetrachloride in Rats

RAYMOND D. MAGUS and JAMES R. FOUTS
Molecular Pharmacology September 1968, 4 (5) 465-470;
RAYMOND D. MAGUS
Department of Pharmacology, University of Iowa College of Medicine, Iowa City, Iowa 62240
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JAMES R. FOUTS
Department of Pharmacology, University of Iowa College of Medicine, Iowa City, Iowa 62240
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Abstract

The inducing action of hydrocortisone and L-tryptophan on hepatic tryptophan pyrrolase in rats treated previously with CCl4 was studied. CCl4 exhibited a dose-dependent (and time-dependent) inhibitory action on the hematin-activated (apoenzyme) form of tryptophan pyrrolase but had no effect on basal holoenzyme activity. A low dose of CCl4 (0.1 ml/kg) abolished induction of the holoenzyme by hydrocortisone but had little effect on the tryptophan-induced holoenzyme or total enzyme activity. This inhibitory action of CCl4 required between 6 and 12 hr of exposure of the animal to CCl4 in vivo, i.e., prior to administration of the inducing agents. A 10-fold increase in CCl4 dose to 1.0 ml/kg did not abolish the inducing action of tryptophan; however, the enzyme response to tryptophan administration was appreciably reduced in rats receiving the higher CCl4 dose.

ACKNOWLEDGMENT This investigation was supported by Grants GM12675 and 5-T01-GM 01308 from the National Institute of General Medical Sciences.

  • Copyright ©, 1968, by Academic Press Inc.

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Molecular Pharmacology
Vol. 4, Issue 5
1 Sep 1968
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Research ArticleArticle

Inhibition of Tryptophan Pyrrolase Induction by Carbon Tetrachloride in Rats

RAYMOND D. MAGUS and JAMES R. FOUTS
Molecular Pharmacology September 1, 1968, 4 (5) 465-470;

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Research ArticleArticle

Inhibition of Tryptophan Pyrrolase Induction by Carbon Tetrachloride in Rats

RAYMOND D. MAGUS and JAMES R. FOUTS
Molecular Pharmacology September 1, 1968, 4 (5) 465-470;
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