Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Molecular Pharmacology
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Molecular Pharmacology

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit molpharm on Facebook
  • Follow molpharm on Twitter
  • Follow molpharm on LinkedIn
Research ArticleArticle

Methanol Metabolism in the Monkey

ADEEB BASSILI MAKAR, T. R. TEPHLY and G. J. MANNERING
Molecular Pharmacology September 1968, 4 (5) 471-483;
ADEEB BASSILI MAKAR
Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 66455
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
T. R. TEPHLY
Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 66455
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
G. J. MANNERING
Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 66455
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

The peroxidative system involving hepatic catalase plays a major role in the oxidation of methanol in the rat (1), but in the monkey the peroxidative mechanism does not appear to be important. This conclusion is based on the following observations: (a) ethanol and methanol were about equally reactive with the peroxidative system, but ethanol was much more reactive with the alcohol dehydrogenase system than methanol. Ethanol was a much more effective inhibitor of methanol oxidation in the intact monkey than it was in the rat, which is what would be expected if methanol is oxidized by the alcohol dehydrogenase system in the monkey, but by the peroxidative system in the rat. (b) By similar reasoning, 1-butanol was a stronger inhibitor of methanol oxidation in the monkey than it should have been if the peroxidative system was involved. (c) 3-Amino-1,2,4-triazole, a potent inhibitor of hepatic catalase, greatly reduced methanol oxidation in the rat, but had no measurable effect on methanol oxidation in the monkey. (d) Ethylene glycol stimulated the rate of methanol oxidation in the rat, probably as a result of an increased H2O2 production that occurs when glycolic acid, a metabolite of ethylene glycol, is oxidized to glyoxylic acid (6,7); no such stimulation was seen in the monkey. Studies in vitro which measured the methanol-oxidizing activity of hepatic alcohol dehydrogenase isolated from monkeys also support the view that this enzyme is largely responsible for methanol oxidation in this species.

ACKNOWLEDGMENTS This research was supported by United States Public Health Service Grant GM-10930. Part of this material appeared in abstract form [Pharmacologist 5, 236 (1963)] and in a thesis by A. B. Makar in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Pharmacology, University of Minnesota, 1966. The authors grate-fully acknowledge the able technical assistance of Mr. Roger Cleve.

  • Copyright ©, 1968, by Academic Press Inc.

MolPharm articles become freely available 12 months after publication, and remain freely available for 5 years. 

Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page. 

 

  • Click here for information on institutional subscriptions.
  • Click here for information on individual ASPET membership.

 

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

Molecular Pharmacology
Vol. 4, Issue 5
1 Sep 1968
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Editorial Board (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Molecular Pharmacology article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Methanol Metabolism in the Monkey
(Your Name) has forwarded a page to you from Molecular Pharmacology
(Your Name) thought you would be interested in this article in Molecular Pharmacology.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

Methanol Metabolism in the Monkey

ADEEB BASSILI MAKAR, T. R. TEPHLY and G. J. MANNERING
Molecular Pharmacology September 1, 1968, 4 (5) 471-483;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

Methanol Metabolism in the Monkey

ADEEB BASSILI MAKAR, T. R. TEPHLY and G. J. MANNERING
Molecular Pharmacology September 1, 1968, 4 (5) 471-483;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Anti-aromatase activity of exemestane phase II metabolites
  • α-Conotoxin Binding Site on the GABAB Receptor
  • Upacicalcet binds to the amino acid binding site of CaSR
Show more Articles

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About Molecular Pharmacology
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Drug Metabolism and Disposition
  • Journal of Pharmacology and Experimental Therapeutics
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-0111 (Online)

Copyright © 2022 by the American Society for Pharmacology and Experimental Therapeutics