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Molecular Pharmacology

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Research ArticleArticle

Mechanism of p-Nitrobenzoate Reduction in Liver: The Possible Role of Cytochrome P-450 in Liver Microsomes

JAMES R. GILLETTE, JEROME J. KAMM and HENRY A. SASAME
Molecular Pharmacology November 1968, 4 (6) 541-548;
JAMES R. GILLETTE
Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Bethesda, Maryland 20014
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JEROME J. KAMM
Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Bethesda, Maryland 20014
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HENRY A. SASAME
Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Bethesda, Maryland 20014
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Abstract

The following evidence suggests that the reduction of p-nitrobenzoate to p-aminobenzoate by liver microsomes is mediated by cytochrome P-450: (a) carbon monoxide blocks nitroreduction, and the degree of inhibition is proportional to the amount of cytochrome P-450 bound as the carbon monoxide complex; (b) the rate of nitroreduction is proportional to the amount of cytochrome P-450 in liver microsomes from animals previously treated with either phenobarbital or carbon tetrachloride.

  • Copyright ©, 1968, by Academic Press Inc.

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Molecular Pharmacology
Vol. 4, Issue 6
1 Nov 1968
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Research ArticleArticle

Mechanism of p-Nitrobenzoate Reduction in Liver: The Possible Role of Cytochrome P-450 in Liver Microsomes

JAMES R. GILLETTE, JEROME J. KAMM and HENRY A. SASAME
Molecular Pharmacology November 1, 1968, 4 (6) 541-548;

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Research ArticleArticle

Mechanism of p-Nitrobenzoate Reduction in Liver: The Possible Role of Cytochrome P-450 in Liver Microsomes

JAMES R. GILLETTE, JEROME J. KAMM and HENRY A. SASAME
Molecular Pharmacology November 1, 1968, 4 (6) 541-548;
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