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Molecular Pharmacology

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Abstract

Isoproterenol-initiated beta-adrenergic receptor diacytosis in cultured cells.

J B Kurz and J P Perkins
Molecular Pharmacology February 1992, 41 (2) 375-381;
J B Kurz
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Abstract

The kinetics of the return of internalized beta-adrenergic receptors to the plasma membrane were measured in human astrocytoma cells. The movement of [125I]iodopindolol-labeled receptors back to the plasma membrane was measured directly and was shown to occur with a t1+2 of 3-4 min. Unlabeled receptors appeared to exhibit the same kinetics of externalization. The process was not inhibited by low concentrations (1-10 microM) of propranolol or even high concentrations of isoproterenol (0.1-1.0 mM). Higher concentrations of propranolol (0.1-1.0 mM) and other lipophilic amines inhibited externalization. The results are consistent with the proposal that catecholamine-induced beta-adrenergic receptor internalization and externalization (diacytosis) occur via the clathrin-coated pit/endosome pathway.

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Molecular Pharmacology
Vol. 41, Issue 2
1 Feb 1992
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Abstract

Isoproterenol-initiated beta-adrenergic receptor diacytosis in cultured cells.

J B Kurz and J P Perkins
Molecular Pharmacology February 1, 1992, 41 (2) 375-381;

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Abstract

Isoproterenol-initiated beta-adrenergic receptor diacytosis in cultured cells.

J B Kurz and J P Perkins
Molecular Pharmacology February 1, 1992, 41 (2) 375-381;
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