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Molecular Pharmacology

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Abstract

Biphasic modulation of the strychnine-sensitive glycine receptor by Zn2+.

A B Bloomenthal, E Goldwater, D B Pritchett and N L Harrison
Molecular Pharmacology December 1994, 46 (6) 1156-1159;
A B Bloomenthal
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E Goldwater
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D B Pritchett
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N L Harrison
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Abstract

The effects of extracellular applications of Zn2+ ions on the strychnine-sensitive glycine receptor were studied in cultured rat spinal cord neurons and with recombinant glycine receptors expressed in human embryonic kidney 293 cells. Nanomolar concentrations of Zn2+ enhanced the chloride ion current in response to brief applications of 100 microM glycine. The enhancement of glycine responses increased from 20 nM to 1 microM Zn2+. Higher concentrations of Zn2+ caused a reversal of the potentiation, followed by progressive inhibition of the glycine response up to approximately 20-50 microM Zn2+. The biphasic modulation by Zn2+ appeared essentially identical in native and recombinant glycine receptors. Biphasic Zn2+ modulation was observed both with picrotoxin-insensitive heteromeric (alpha 2/beta) receptors and with picrotoxin-sensitive homomeric receptors consisting only of alpha 2 subunits. This suggests that the alpha subunit alone is sufficient for formation of two distinct Zn2+ binding sites on the glycine receptor. The demonstration of Zn2+ modulation of the strychnine-sensitive glycine receptor is of potential physiological importance, in view of the likely range of subsynaptic Zn2+ concentrations to which the receptor is exposed.

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Molecular Pharmacology
Vol. 46, Issue 6
1 Dec 1994
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Abstract

Biphasic modulation of the strychnine-sensitive glycine receptor by Zn2+.

A B Bloomenthal, E Goldwater, D B Pritchett and N L Harrison
Molecular Pharmacology December 1, 1994, 46 (6) 1156-1159;

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Abstract

Biphasic modulation of the strychnine-sensitive glycine receptor by Zn2+.

A B Bloomenthal, E Goldwater, D B Pritchett and N L Harrison
Molecular Pharmacology December 1, 1994, 46 (6) 1156-1159;
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