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Molecular Pharmacology

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Abstract

D609, a phosphatidylcholine-specific phospholipase C inhibitor, blocks interleukin-1 beta-induced vascular cell adhesion molecule 1 gene expression in human endothelial cells.

R R Cobb, K A Felts, G C Parry and N Mackman
Molecular Pharmacology June 1996, 49 (6) 998-1004;
R R Cobb
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K A Felts
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G C Parry
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N Mackman
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Abstract

At sites of inflammation, endothelial cells play a major role in defining the types of leukocytes that are recruited to a specific area. This is accomplished, at least in part, through the cytokine induction of cell surface adhesion molecules, including vascular cell adhesion molecule 1 (VCAM-1). We investigated the role of phosphatidylcholine-specific phospholipase C in the induction of VCAM-1 gene expression by interleukin-1 beta. D609, a phosphatidylcholine-specific phospholipase C inhibitor, reduced VCAM-1 cell surface expression and VCAM-1 promoter activity in human endothelial cells in a dose-dependent manner. D609 did not affect nuclear translocation of nuclear factor-kappa B but inhibited nuclear factor-kappa B-mediated transcription. The results of this study indicate that phosphatidylcholine-specific phospholipase C is required for activation of nuclear factor-kappa B and cytokine induction of VCAM-1 gene expression in endothelial cells.

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Molecular Pharmacology
Vol. 49, Issue 6
1 Jun 1996
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Abstract

D609, a phosphatidylcholine-specific phospholipase C inhibitor, blocks interleukin-1 beta-induced vascular cell adhesion molecule 1 gene expression in human endothelial cells.

R R Cobb, K A Felts, G C Parry and N Mackman
Molecular Pharmacology June 1, 1996, 49 (6) 998-1004;

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Abstract

D609, a phosphatidylcholine-specific phospholipase C inhibitor, blocks interleukin-1 beta-induced vascular cell adhesion molecule 1 gene expression in human endothelial cells.

R R Cobb, K A Felts, G C Parry and N Mackman
Molecular Pharmacology June 1, 1996, 49 (6) 998-1004;
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