Abstract
The reduction of p-nitrobenzoate by an NADPH-dependent enzyme in liver microsomes is presumably mediated by cytochrome P-450. The reaction is inhibited by substances which cause type II spectral changes in liver microsomes, but not by those which cause type I spectral changes. Type II substances inhibit only about 50% of the nitroreductase activity in liver microsomes. The apparent Ki values for the inhibition of p-nitrobenzoate reduction are approximately double the K[unknown], values of the various type II substances studied. The evidence suggests that type II substances inhibit p-nitrobenzoate reduction by slowing the rate of cytochrome P-450 reduction.
- Copyright ©, 1969, by Academic Press Inc.
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