Table of Contents

Articles

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  Coordinate Regulation of Stress- and Mitogen-Activated Protein Kinases in the Apoptotic Actions of Ceramide and Sphingosine

  W. David Jarvis, Frank A. Fornari, Kelly L. Auer, Alex J. Freemerman, Eva Szabo, Michael J. Birrer, Charlene R. Johnson, Suzanne E. Barbour, Paul Dent and Steven Grant

  Molecular Pharmacology December 1997, 52 (6) 935-947; DOI: https://doi.org/10.1124/mol.52.6.935
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  Characterization of a Novel Bisacridone and Comparison with PSC 833 as a Potent and Poorly Reversible Modulator of P-Glycoprotein

  Julie K. Horton, Kuntebommanahalli N. Thimmaiah, Guillermo A. Altenberg, Ariel F. Castro, Glen S. Germain, G. Krishne Gowda and Peter J. Houghton

  Molecular Pharmacology December 1997, 52 (6) 948-957; DOI: https://doi.org/10.1124/mol.52.6.948
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  Characterization of a Human GlutathioneS-Transferase μ Cluster Containing a DuplicatedGSTM1 Gene that Causes Ultrarapid Enzyme Activity

  Roman A. McLellan, Mikael Oscarson, Anna-Karin Alexandrie, Janeric Seidegård, David A. Price Evans, Agneta Rannug and Magnus Ingelman-Sundberg

  Molecular Pharmacology December 1997, 52 (6) 958-965; DOI: https://doi.org/10.1124/mol.52.6.958
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  Regulation of m2 Muscarinic Receptor Gene Expression by Platelet-Derived Growth Factor: Involvement of Extracellular Signal-Regulated Protein Kinases in the Down-Regulation Process

  Jonathan Rousell, El-Bdaoui Haddad, Mark A. Lindsay and Peter J. Barnes

  Molecular Pharmacology December 1997, 52 (6) 966-973; DOI: https://doi.org/10.1124/mol.52.6.966
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  Identification of Benzo[a]pyrene-InducibleCis-Acting Elements Within c-Ha-rasTranscriptional Regulatory Sequences

  C. M. Bral and K. S. Ramos

  Molecular Pharmacology December 1997, 52 (6) 974-982; DOI: https://doi.org/10.1124/mol.52.6.974
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  Naloxone Activation of μ-Opioid Receptors Mutated at a Histidine Residue Lining the Opioid Binding Cavity

  Charles E. Spivak, Carol L. Beglan, Brian K. Seidleck, Laura D. Hirshbein, Carrie J. Blaschak, George R. Uhl and Christopher K. Surratt

  Molecular Pharmacology December 1997, 52 (6) 983-992; DOI: https://doi.org/10.1124/mol.52.6.983
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  Enhanced Stimulatory Adenylyl Cyclase Signaling during Opioid Dependence Is Associated with a Reduction in Palmitoylated G_sα

  Hermann Ammer and Rüdiger Schulz

  Molecular Pharmacology December 1997, 52 (6) 993-999; DOI: https://doi.org/10.1124/mol.52.6.993
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  Agents that Down-Regulate or Inhibit Protein Kinase C Circumvent Resistance to 1-β-D-Arabinofuranosylcytosine-Induced Apoptosis in Human Leukemia Cells that Overexpress Bcl-2

  Shujie Wang, Julie A. Vrana, Tina M. Bartimole, Alex J. Freemerman, W. David Jarvis, Lora B. Kramer, Geoffrey Krystal, Paul Dent and Steven Grant

  Molecular Pharmacology December 1997, 52 (6) 1000-1009; DOI: https://doi.org/10.1124/mol.52.6.1000
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  Proximal Nephron Na⁺/H⁺ Exchange Is Regulated by α_1A- and α_1B-Adrenergic Receptor Subtypes

  Fengming Liu, Teresa Nesbitt, Marc K. Drezner, Peter A. Friedman and Frank A. Gesek

  Molecular Pharmacology December 1997, 52 (6) 1010-1018; DOI: https://doi.org/10.1124/mol.52.6.1010
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  Both the Cyclic AMP Response Element and the Activator Protein 2 Binding Site Mediate Basal and Cyclic AMP-Induced Transcription from the Dominant Promoter of the Rat α_1B-Adrenergic Receptor Gene in DDT₁MF-2 Cells

  Bin Gao, Jianping Chen, Carl Johnson and George Kunos

  Molecular Pharmacology December 1997, 52 (6) 1019-1026; DOI: https://doi.org/10.1124/mol.52.6.1019
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  Neuropeptide Y Inhibits Chromaffin Cell Nicotinic Receptor-Stimulated Tyrosine Hydroxylase Activity through a Receptor-Linked G Protein-Mediated Process

  Jialin Zheng, Peijin Zhang and Terry D. Hexum

  Molecular Pharmacology December 1997, 52 (6) 1027-1033; DOI: https://doi.org/10.1124/mol.52.6.1027
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  A Combination of Mutations in the CYP2D6*17(CYP2D6Z) Allele Causes Alterations in Enzyme Function

  Mikael Oscarson, Mats Hidestrand, Inger Johansson and Magnus Ingelman-Sundberg

  Molecular Pharmacology December 1997, 52 (6) 1034-1040; DOI: https://doi.org/10.1124/mol.52.6.1034
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  Potent Inhibitors of Human Immunodeficiency Virus Type 1 Integrase: Identification of a Novel Four-Point Pharmacophore and Tetracyclines as Novel Inhibitors

  Nouri Neamati, Huixiao Hong, Sanjay Sunder, George W. A. Milne and Yves Pommier

  Molecular Pharmacology December 1997, 52 (6) 1041-1055; DOI: https://doi.org/10.1124/mol.52.6.1041
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  Antisense Inhibition of 5-Hydroxytryptamine_2aReceptor Induces an Antidepressant-Like Effect in Mice

  Etienne Sibille, Zoltan Sarnyai, Daniel Benjamin, Judit Gal, Harriet Baker and Miklos Toth

  Molecular Pharmacology December 1997, 52 (6) 1056-1063; DOI: https://doi.org/10.1124/mol.52.6.1056
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  Role of G_αq or G_αo Proteins in α₁-Adrenoceptor Subtype-Mediated Responses in Fischer 344 Rat Aorta

  Hakan Gurdal, Tammy M. Seasholtz, Hoau-Yan Wang, R. Dale Brown, Mark D. Johnson and Eitan Friedman

  Molecular Pharmacology December 1997, 52 (6) 1064-1070; DOI: https://doi.org/10.1124/mol.52.6.1064
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  Distribution of mRNA Encoding Three α₂-Adrenergic Receptor Subtypes in the Developing Mouse Embryo Suggests a Role for the α_2A Subtype in Apoptosis

  Ren-Xue Wang and Lee E. Limbird

  Molecular Pharmacology December 1997, 52 (6) 1071-1080; DOI: https://doi.org/10.1124/mol.52.6.1071
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  In Vivo Production of Nitric Oxide in Rats after Administration of Hydroxyurea

  Jinjie Jiang, Sandra J. Jordan, David P. Barr, Michael R. Gunther, Hiroshi Maeda and Ronald P. Mason

  Molecular Pharmacology December 1997, 52 (6) 1081-1086; DOI: https://doi.org/10.1124/mol.52.6.1081
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  Site-Directed Mutagenesis on the m2 Muscarinic Acetylcholine Receptor: The Significance of Tyr403 in the Binding of Agonists and Functional Coupling

  Walter K. Vogel, David M. Sheehan and Michael I. Schimerlik

  Molecular Pharmacology December 1997, 52 (6) 1087-1094; DOI: https://doi.org/10.1124/mol.52.6.1087
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  Voltage-Dependent Inhibition of N- and P-Type Calcium Channels by the Peptide Toxin ω-Grammotoxin-SIA

  Stefan I. McDonough, Richard A. Lampe, Richard A. Keith and Bruce P. Bean

  Molecular Pharmacology December 1997, 52 (6) 1095-1104; DOI: https://doi.org/10.1124/mol.52.6.1095
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  Functional Deactivation of the Major Neuronal Nicotinic Receptor Caused by Nicotine and a Protein Kinase C-Dependent Mechanism

  Helge Eilers, Eric Schaeffer, Philip E. Bickler and John R. Forsayeth

  Molecular Pharmacology December 1997, 52 (6) 1105-1112; DOI: https://doi.org/10.1124/mol.52.6.1105
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  Distinct Sites for Inverse Modulation ofN-Methyl-d-Aspartate Receptors by Sulfated Steroids

  Mijeong Park-Chung, Fong-Sen Wu, Robert H. Purdy, Andrew A. Malayev, Terrell T. Gibbs and David H. Farb

  Molecular Pharmacology December 1997, 52 (6) 1113-1123; DOI: https://doi.org/10.1124/mol.52.6.1113
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  Ca²⁺ Feedback on “Quantal” Ca²⁺Release Involving Ryanodine Receptors

  Christine Dettbarn and Philip Palade

  Molecular Pharmacology December 1997, 52 (6) 1124-1130; DOI: https://doi.org/10.1124/mol.52.6.1124
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  KvLQT1 Potassium Channel but Not IsK Is the Molecular Target fortrans-6-Cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethyl-chromane

  Gildas Loussouarn, Flavien Charpentier, Raha Mohammad-Panah, Karl Kunzelmann, Isabelle Baró and Denis Escande

  Molecular Pharmacology December 1997, 52 (6) 1131-1136; DOI: https://doi.org/10.1124/mol.52.6.1131
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  Constitutive Activity of a Chimeric D₂/D₁Dopamine Receptor

  Laura B. Kozell and Kim A. Neve

  Molecular Pharmacology December 1997, 52 (6) 1137-1149; DOI: https://doi.org/10.1124/mol.52.6.1137
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  Differences in Agonist/Antagonist Binding Affinity and Receptor Transduction Using Recombinant Human γ-Aminobutyric Acid Type A Receptors

  Bjarke Ebert, Sally A. Thompson, Koralia Saounatsou, Ruth McKernan, Povl Krogsgaard-Larsen and Keith A. Wafford

  Molecular Pharmacology December 1997, 52 (6) 1150-1156; DOI: https://doi.org/10.1124/mol.52.6.1150
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  S -Adenosylhomocysteine Hydrolase Inhibitors Interfere with the Replication of Human Immunodeficiency Virus Type 1 through Inhibition of the LTR Transactivation

  Dirk Daelemans, Jose A. Esté, Myriam Witvrouw, Christophe Pannecouque, Heidi Jonckheere, Stefano Aquaro, Carlo-Federico Perno, Erik De Clercq and Anne-Mieke Vandamme

  Molecular Pharmacology December 1997, 52 (6) 1157-1163; DOI: https://doi.org/10.1124/mol.52.6.1157
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  Expression Cloning and Receptor Pharmacology of Human Calcitonin Receptors from MCF-7 Cells and Their Relationship to Amylin Receptors

  Wen-Ji Chen, Susan Armour, James Way, Grace Chen, Chris Watson, Paul Irving, Jeff Cobb, Sue Kadwell, Kevin Beaumont, Tom Rimele and Terry Kenakin

  Molecular Pharmacology December 1997, 52 (6) 1164-1175; DOI: https://doi.org/10.1124/mol.52.6.1164