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Rapid CommunicationAccelerated Communication

Activation by Diverse Xenochemicals of the 51-Base Pair Phenobarbital-Responsive Enhancer Module in the CYP2B10Gene

Paavo Honkakoski, Rick Moore, Kimberly A. Washburn and Masahiko Negishi
Molecular Pharmacology April 1998, 53 (4) 597-601; DOI: https://doi.org/10.1124/mol.53.4.597
Paavo Honkakoski
Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709
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Rick Moore
Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709
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Kimberly A. Washburn
Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709
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Masahiko Negishi
Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709
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Abstract

By extending previous studies of the phenobarbital (PB)-responsive 132-base pair (bp) enhancer sequence in the CYP2B10gene, we have delimited a 51-bp enhancer element that is fully inducible by PB in mouse primary hepatocytes. Sixteen structurally unrelated phenobarbital-type inducers activated the 51-bp enhancer element in transient transfection assays. The results thus indicate that most PB-type inducers, if not all inducers, increase the transcription of the CYP2B10 gene by activating this 51-bp element, now designated PB-responsive enhancer module or PBREM.

Footnotes

    • Received December 12, 1997.
    • Accepted January 9, 1998.
  • Send reprint requests to: Dr. Masahiko Negishi, Pharmacogenetics Section, Lab of Reproductive and Developmental Toxicology, NIEHS, NIH, Research Triangle Park, NC 27709. E-mail:negishi{at}niehs.nih.gov

  • ↵1 Current affiliation: Department of Pharmaceutics, University of Kuopio, FIN-70211 Kuopio, Finland.

  • The American Society for Pharmacology and Experimental Therapeutics
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Molecular Pharmacology: 53 (4)
Molecular Pharmacology
Vol. 53, Issue 4
1 Apr 1998
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Rapid CommunicationAccelerated Communication

Activation by Diverse Xenochemicals of the 51-Base Pair Phenobarbital-Responsive Enhancer Module in the CYP2B10Gene

Paavo Honkakoski, Rick Moore, Kimberly A. Washburn and Masahiko Negishi
Molecular Pharmacology April 1, 1998, 53 (4) 597-601; DOI: https://doi.org/10.1124/mol.53.4.597

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Rapid CommunicationAccelerated Communication

Activation by Diverse Xenochemicals of the 51-Base Pair Phenobarbital-Responsive Enhancer Module in the CYP2B10Gene

Paavo Honkakoski, Rick Moore, Kimberly A. Washburn and Masahiko Negishi
Molecular Pharmacology April 1, 1998, 53 (4) 597-601; DOI: https://doi.org/10.1124/mol.53.4.597
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